Optimum Design of Surface Plasmon Resonance (SPR) Tapered Fiber Optic Biosensing Probe With Graphene–MoS2 Over Layers for DNA Hybridization

A novel graphene/MoS2-coated tapered fiber optic surface plasmon resonance (SPR) biosensing probe is presented for the first time to analyze the deoxyribonucleic acid (DNA) hybridization working in the near-infrared region (IR) of the electromagnetic spectrum with improved performance. A proper optimization mechanism is devised to study DNA hybridization concerning the taper ratio. A transfer matrix method (TMM) has been envisaged to study various performance parameters such as the figure of merit (F.O.M.), detection accuracy (D.A.), full width at half maximum (FWHM), and sensitivity. The proposed biosensor is very effectively able to distinguish between DNA hybridization and single-nucleotide polymorphisms (SNPs) by observing a considerable shift in SPR resonance wavelength and transmission dip. Due to the effect of optimized graphene/MoS2 nanostructured and tapering section of fiber, the proposed SPR biosensor work in the near-IR region is very much advantageous for further scope of sensing technology.