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Role of Pyramidal Cell M-current in Weak Pyramidal/Interneuronal Gamma Cluster Formation | IEEE Conference Publication | IEEE Xplore

Role of Pyramidal Cell M-current in Weak Pyramidal/Interneuronal Gamma Cluster Formation

Publisher: IEEE

Abstract:

In the cortex gamma oscillations, generated in the networks consisting of pyramidal cells and interneurons, are typically irregular and sparse. Taking into account differ...View more

Abstract:

In the cortex gamma oscillations, generated in the networks consisting of pyramidal cells and interneurons, are typically irregular and sparse. Taking into account differences in the firing frequencies of pyramidal cells and interneurons, it is possible to conclude that a probable way of modelling of these gamma features is generation of the oscillations by alternating firing of the pyramidal cell clusters. Muscarine-sensitive potassium current (M-current) together with AHP-current plays important role in intrinsic dynamics of the pyramidal cells. In particular, it dampens the excitability (decreasing the spiking state range in the parameter space) and changes the excitability type of the pyramidal cells. These crucially act on the cluster formation process in the pyramidal subnetwork altering the number of clusters and, thus, coherence of the gamma rhythm.
Date of Conference: 07-09 September 2020
Date Added to IEEE Xplore: 08 October 2020
ISBN Information:
Publisher: IEEE
Conference Location: Innopolis, Russia

References

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