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Progress in Nanorobotics for Advancing Biomedicine | IEEE Journals & Magazine | IEEE Xplore

Progress in Nanorobotics for Advancing Biomedicine


Abstract:

Nanorobotics, which has long been a fantasy in the realm of science fiction, is now a reality due to the considerable developments in diverse fields including chemistry, ...Show More

Abstract:

Nanorobotics, which has long been a fantasy in the realm of science fiction, is now a reality due to the considerable developments in diverse fields including chemistry, materials, physics, information and nanotechnology in the past decades. Not only different prototypes of nanorobots whose sizes are nanoscale are invented for various biomedical applications, but also robotic nanomanipulators which are able to handle nano-objects obtain substantial achievements for applications in biomedicine. The outstanding achievements in nanorobotics have significantly expanded the field of medical robotics and yielded novel insights into the underlying mechanisms guiding life activities, remarkably showing an emerging and promising way for advancing the diagnosis & treatment level in the coming era of personalized precision medicine. In this review, the recent advances in nanorobotics (nanorobots, nanorobotic manipulations) for biomedical applications are summarized from several facets (including molecular machines, nanomotors, DNA nanorobotics, and robotic nanomanipulators), and the future perspectives are also presented.
Published in: IEEE Transactions on Biomedical Engineering ( Volume: 68, Issue: 1, January 2021)
Page(s): 130 - 147
Date of Publication: 27 April 2020

ISSN Information:

PubMed ID: 32340931

Funding Agency:


I. Introduction

The developments of medical robotics in the past decades have contributed much to the field of clinical medicine. Medical robots fundamentally couple information [including patient-specific information (e.g., medical images and lab test results) and general information (e.g., anatomic atlases, statistics, and rules)] to physical action to significantly enhance humans’ ability to perform various medical tasks, and the medical tasks are often surgical interventions, rehabilitation, or helping handicapped people in daily living for macroscale medical robotics [1]–[4]. The use of surgical robots (e.g., the well-known da Vinci robot system) brings enhanced dexterity, greater precision, reduced surgeon hand-tremor, intuitive ergonomic interfaces, and the ability to access surgical sites remotely with miniaturized instrumentation, significantly benefiting minimally invasive surgery [5], [6]. Robotic devices have been developed to restore the functionality of patients with movement disorders, such as upper limb rehabilitation [7] and lower limb assistance [8]. Wireless video capsule endoscopy enables inspection of the digestive system without discomfort or need for sedation and has the potential of encouraging patients to undergo gastrointestinal tract tests [9], which has revolutionized the diagnostic work-up in the field of small bowel diseases [10]. The emergence of soft robotics, which uses soft materials with biocompatibility and biomimicry, has opened possibilities for novel biomedical applications in which a soft interaction with a patient is preferred [11], [12]. Hand-held robots, which are totally ungrounded and manipulated by surgeons in free space, provide specific functions to assist the surgeon in accomplishing tasks that are otherwise challenging with manual manipulation [13]. These achievements in macroscale medical robotics undeniably show the impacts of robotics on clinical medicine and healthcare [14], [15].

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References

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