I. Introduction
X-ray computed tomography (CT) is one of the most important imaging modalities in modern hospitals and clinics. However, there is a potential radiation risk to the patient, since x-rays could cause genetic damage and induce cancer in a probability related to the radiation dose [1], [2]. Lowering the radiation dose increases the noise and artifacts in reconstructed images, which can compromise diagnostic information. Hence, extensive efforts have been made to design better image reconstruction or image processing methods for low-dose CT (LDCT). These methods generally fall into three categories: (a) sinogram filtration before reconstruction [3]–[5], (b) iterative reconstruction [6], [7], and (c) image post-processing after reconstruction [8]–[10].