Evaluation of maintained effect of hypertonic saline solution in Guyton's closed-loop model

This paper aims to evaluate the sustainable effect of hypertonic saline solution in Guyton's closed loop model. A model involves the correlation of mean arterial pressure (MAP), heart rate (HR), and cardiac output (CO) is created for investigation. The developed model is then compared with the cardiovascular dynamics system originally schemed by Guyton in 1972. The output results from closed-loop circuitry simulation show a +/−5.86 % difference to the Guyton 1972 model's outputs and less than a +/− 2% difference to the steady state values. The effect of hypertonic saline thought short-lived but stimulated excess body fluid excretion moderately as expected.