I. Introduction
Arterial stiffness is recognized as an important contributor to the development of cardiovascular diseases. Central (aortic) stiffness is highlighted because of its independent predictive value for all-cause and cardiovascular mortalities, coronary events, fatal strokes in elderly subjects and patients with end-stage renal disease, hypertension and impaired glucose tolerance [1]. Meanwhile, the importance of peripheral (especially lower-limbs) stiffness is underestimated although it is involved in the development of peripheral artery disease [2] and diabetic peripheral neuropathy [3]. Therefore it is important to include a parameter, which is capable to assess central and peripheral stiffness and at the same time which is non-invasive and convenient enough to become part of longterm periodic monitoring of patients with chronic diseases.