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Extracellular calcium and L-type calcium current inactivation mechanisms: A computational study | IEEE Conference Publication | IEEE Xplore

Extracellular calcium and L-type calcium current inactivation mechanisms: A computational study


Abstract:

Extracellular calcium concentration ([Ca2+]o) affects cardiac action potential (AP): their inverse dependence has already been assessed in vivo and in vitro. Both shorten...Show More

Abstract:

Extracellular calcium concentration ([Ca2+]o) affects cardiac action potential (AP): their inverse dependence has already been assessed in vivo and in vitro. Both shortening and prolongation of AP are associated with an increased risk of arrhythmias and Ca2+ variations may occur in many different contexts (e.g. pathological hypo/hypercalcemia, haemodialysis therapy, bed-rest experiments). Computational modeling could provide a useful support to investigate this phenomenon: however, [Ca2+]0 dependence is not reproduced properly by most of the commonly used human AP models The aim of this study has been to modify one of the most recent human ventricular cell model in order to improve its response to [Ca2+]0 changes. The modified model has been validated against the same experimental data used for the original one, in order to verify its consistency, and it can thus be used to explore "in silico" the effects of electrolyte unbalances on the electrical activity of human cardiomyocytes.
Date of Conference: 22-25 September 2013
Date Added to IEEE Xplore: 16 January 2014
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Conference Location: Zaragoza, Spain

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