The feature of resonance of gene expression and identification of the genes associated with Alzheimer's disease

Alzheimer's disease (AD) is the most common type of dementia and the amount of risk of AD that is attributable to genetics is estimated to be around 70%. Since 2000, cDNA microarray technology is used to identify AD-related gene (ADG), and the commonly used criterion of identification is the up-regulation or down-regulation of genes. In this paper, the following feature named resonance of gene expression is observed from gene expression profile of AD: Some genes change their expression levels synchronously with a given ADG at uncontrolled stage while their expressions are independent to the ADG at control stage. This feature likes the resonance of wave or the synchronization of a group of dancers. The genes holding this feature are related to AD potentially and are identified as the candidate ADGs. The shown characteristic at Fig. 1 is suggested with the result 0 f famous Prof Goate's group on Feb. 2012.