Abstract:
Data-driven techniques have recently drawn significant interest in the predictive modeling of subcutaneous (s.c.) glucose concentration in type 1 diabetes. In this study,...Show MoreMetadata
Abstract:
Data-driven techniques have recently drawn significant interest in the predictive modeling of subcutaneous (s.c.) glucose concentration in type 1 diabetes. In this study, the s.c. glucose prediction is treated as a multivariate regression problem, which is addressed using support vector regression (SVR). The proposed method is based on variables concerning: 1) the s.c. glucose profile; 2) the plasma insulin concentration; 3) the appearance of meal-derived glucose in the systemic circulation; and 4) the energy expenditure during physical activities. Six cases corresponding to different combinations of the aforementioned variables are used to investigate the influence of the input on the daily glucose prediction. The proposed method is evaluated using a dataset of 27 patients in free-living conditions. Tenfold cross validation is applied to each dataset individually to both optimize and test the SVR model. In the case, where all the input variables are considered, the average prediction errors are 5.21, 6.03, 7.14, and 7.62 mg/dl for 15-, 30-, 60-, and 120-min prediction horizons, respectively. The results clearly indicate that the availability of multivariable data and their effective combination can significantly increase the accuracy of both short-term and long-term predictions.
Published in: IEEE Journal of Biomedical and Health Informatics ( Volume: 17, Issue: 1, January 2013)
Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece
Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
Eleni I. Georga was born in Sparti, Greece, in 1981. She received the B.Sc. and M.Sc. degrees from the Department of Computer Science, University of Ioannina, Ioannina, Greece, in 2005 and 2008, respectively, where she is currently working toward the Ph.D. degree in the Department of Materials Science and Engineering.
She is also with the Unit of Medical Technology and Intelligent Information Systems, University of Ioannin...Show More
Eleni I. Georga was born in Sparti, Greece, in 1981. She received the B.Sc. and M.Sc. degrees from the Department of Computer Science, University of Ioannina, Ioannina, Greece, in 2005 and 2008, respectively, where she is currently working toward the Ph.D. degree in the Department of Materials Science and Engineering.
She is also with the Unit of Medical Technology and Intelligent Information Systems, University of Ioannin...View more
Department ofMechanical Engineering and Aeronautics, University of Patras, Patras, Greece
Vasilios C. Protopappas was born in Ioannina, Greece, in 1976. He received the Diploma degree in electrical and computer engineering from the National Technical University of Athens, Athens, Greece, in 1999, the M.Sc. degree in bioengineering from the University of Strathclyde, Glasgow, U.K., in 2000, and the Ph.D. degree from the Department of Medical Physics, Medical School, University of Ioannina, Ioannina, Greece, in ...Show More
Vasilios C. Protopappas was born in Ioannina, Greece, in 1976. He received the Diploma degree in electrical and computer engineering from the National Technical University of Athens, Athens, Greece, in 1999, the M.Sc. degree in bioengineering from the University of Strathclyde, Glasgow, U.K., in 2000, and the Ph.D. degree from the Department of Medical Physics, Medical School, University of Ioannina, Ioannina, Greece, in ...View more
Chiesi Farmaceutici SpA, Parma, Italy
Diego Ardigò received the Medical degree from the University of Parma, Parma, Italy, in 2000 and the specialization in internal medicine in 2005, and received the Ph.D. degree in systemic pathophysiology from the University of Parma, in 2010.
He was awarded a Postgraduate Fellowship in Cardiovascular Genomics at Stanford University, Stanford, CA, during 2004–2005. He is currently a Clinical Research Physician and Clinical ...Show More
Diego Ardigò received the Medical degree from the University of Parma, Parma, Italy, in 2000 and the specialization in internal medicine in 2005, and received the Ph.D. degree in systemic pathophysiology from the University of Parma, in 2010.
He was awarded a Postgraduate Fellowship in Cardiovascular Genomics at Stanford University, Stanford, CA, during 2004–2005. He is currently a Clinical Research Physician and Clinical ...View more
Department of Internal Medicine, University of Parma, Parma, Italy
Michela Marina received the Medical degree (cum laude) from the University of Parma, Parma, Italy, in 2008, where she is currently attending the specialization in endocrinology and metabolic disease.
During the postgraduate school, she is acquiring expertise in the management of endocrine-metabolic disorders, performing clinical activity for the following diseases: diabetes mellitus, with particular reference to patients w...Show More
Michela Marina received the Medical degree (cum laude) from the University of Parma, Parma, Italy, in 2008, where she is currently attending the specialization in endocrinology and metabolic disease.
During the postgraduate school, she is acquiring expertise in the management of endocrine-metabolic disorders, performing clinical activity for the following diseases: diabetes mellitus, with particular reference to patients w...View more
Department of Internal Medicine, University of Parma, Parma, Italy
Ivana Zavaroni received the degree in medicine and surgery (summa cum laude) from the University of Parma, Parma, Italy, in 1973, the specialization in cardiology from the University of Siena, Siena, Italy, in 1976, the specialization in diabetes from the University of Parma, in 1978, and the specialization in nutrition from the University of Pavia, Pavia, Italy, in 1989.
She is currently a Professor of Endocrinology in th...Show More
Ivana Zavaroni received the degree in medicine and surgery (summa cum laude) from the University of Parma, Parma, Italy, in 1973, the specialization in cardiology from the University of Siena, Siena, Italy, in 1976, the specialization in diabetes from the University of Parma, in 1978, and the specialization in nutrition from the University of Pavia, Pavia, Italy, in 1989.
She is currently a Professor of Endocrinology in th...View more
Department ofMechanical Engineering and Aeronautics, University of Patras, Patras, Greece
Demosthenes Polyzos was born in Karditsa, Greece, in 1958. He received the Diploma and Ph.D. degrees in mechanical engineering from the University of Patras, Patras, Greece, in 1981 and 1987, respectively.
Since 1982, he has been in the Department of Mechanical Engineering and Aeronautics, University of Patras, where he is currently a Professor. He has published more than 65 papers in scientific journals and more than 120 ...Show More
Demosthenes Polyzos was born in Karditsa, Greece, in 1958. He received the Diploma and Ph.D. degrees in mechanical engineering from the University of Patras, Patras, Greece, in 1981 and 1987, respectively.
Since 1982, he has been in the Department of Mechanical Engineering and Aeronautics, University of Patras, where he is currently a Professor. He has published more than 65 papers in scientific journals and more than 120 ...View more
Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
Dimitrios I. Fotiadis (M’01–SM’06) was born in Ioannina, Greece, in 1961. He received the Diploma degree in chemical engineering from the Department of Chemical Engineering, National Technical University of Athens, Athens, Greece, in 1985, and the Ph.D. degree in chemical engineering and materials science from the University of Minnesota, Twin Cities, Minneapolis, in 1990.
He is currently a Professor of Biomedical Engineer...Show More
Dimitrios I. Fotiadis (M’01–SM’06) was born in Ioannina, Greece, in 1961. He received the Diploma degree in chemical engineering from the Department of Chemical Engineering, National Technical University of Athens, Athens, Greece, in 1985, and the Ph.D. degree in chemical engineering and materials science from the University of Minnesota, Twin Cities, Minneapolis, in 1990.
He is currently a Professor of Biomedical Engineer...View more
Contents Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece
Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
Eleni I. Georga was born in Sparti, Greece, in 1981. She received the B.Sc. and M.Sc. degrees from the Department of Computer Science, University of Ioannina, Ioannina, Greece, in 2005 and 2008, respectively, where she is currently working toward the Ph.D. degree in the Department of Materials Science and Engineering.
She is also with the Unit of Medical Technology and Intelligent Information Systems, University of Ioannina. From 2008 to 2012 till date, she is a Researcher in the Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece. Her research interests include bioinformatics, computational intelligence, and predictive modeling of physiological systems.
Eleni I. Georga was born in Sparti, Greece, in 1981. She received the B.Sc. and M.Sc. degrees from the Department of Computer Science, University of Ioannina, Ioannina, Greece, in 2005 and 2008, respectively, where she is currently working toward the Ph.D. degree in the Department of Materials Science and Engineering.
She is also with the Unit of Medical Technology and Intelligent Information Systems, University of Ioannina. From 2008 to 2012 till date, she is a Researcher in the Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece. Her research interests include bioinformatics, computational intelligence, and predictive modeling of physiological systems.View more
Department ofMechanical Engineering and Aeronautics, University of Patras, Patras, Greece
Vasilios C. Protopappas was born in Ioannina, Greece, in 1976. He received the Diploma degree in electrical and computer engineering from the National Technical University of Athens, Athens, Greece, in 1999, the M.Sc. degree in bioengineering from the University of Strathclyde, Glasgow, U.K., in 2000, and the Ph.D. degree from the Department of Medical Physics, Medical School, University of Ioannina, Ioannina, Greece, in 2006.
From 2000 to 2007, he worked with the Unit of Medical Technology and Intelligent Information Systems, University of Ioannina. He is currently a Postdoctoral Researcher in the Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece. He has published 18 papers in peer-reviewed journals, four book chapters, one international patent, more than 40 papers in international conferences and has also received three awards from international scientific committees. His research interests include computational biomechanics, ultrasonic testing, wearable ultrasound devices, biosignal analysis, patient monitoring systems, clinical decision support systems, and chronic disease management.
Vasilios C. Protopappas was born in Ioannina, Greece, in 1976. He received the Diploma degree in electrical and computer engineering from the National Technical University of Athens, Athens, Greece, in 1999, the M.Sc. degree in bioengineering from the University of Strathclyde, Glasgow, U.K., in 2000, and the Ph.D. degree from the Department of Medical Physics, Medical School, University of Ioannina, Ioannina, Greece, in 2006.
From 2000 to 2007, he worked with the Unit of Medical Technology and Intelligent Information Systems, University of Ioannina. He is currently a Postdoctoral Researcher in the Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece. He has published 18 papers in peer-reviewed journals, four book chapters, one international patent, more than 40 papers in international conferences and has also received three awards from international scientific committees. His research interests include computational biomechanics, ultrasonic testing, wearable ultrasound devices, biosignal analysis, patient monitoring systems, clinical decision support systems, and chronic disease management.View more
Chiesi Farmaceutici SpA, Parma, Italy
Diego Ardigò received the Medical degree from the University of Parma, Parma, Italy, in 2000 and the specialization in internal medicine in 2005, and received the Ph.D. degree in systemic pathophysiology from the University of Parma, in 2010.
He was awarded a Postgraduate Fellowship in Cardiovascular Genomics at Stanford University, Stanford, CA, during 2004–2005. He is currently a Clinical Research Physician and Clinical Development Leader for stem cell-based products at Chiesi Farmaceutici SpA, Parma, and additional consultancy activities with public institutions, including the University of Parma. He authored several publications in peer-review medical journals. His research interests include diabetes, metabolism, and cardiovascular diseases with a specific interest in information communication technology applications for health and large throughput data gathering and integration.
Diego Ardigò received the Medical degree from the University of Parma, Parma, Italy, in 2000 and the specialization in internal medicine in 2005, and received the Ph.D. degree in systemic pathophysiology from the University of Parma, in 2010.
He was awarded a Postgraduate Fellowship in Cardiovascular Genomics at Stanford University, Stanford, CA, during 2004–2005. He is currently a Clinical Research Physician and Clinical Development Leader for stem cell-based products at Chiesi Farmaceutici SpA, Parma, and additional consultancy activities with public institutions, including the University of Parma. He authored several publications in peer-review medical journals. His research interests include diabetes, metabolism, and cardiovascular diseases with a specific interest in information communication technology applications for health and large throughput data gathering and integration.View more
Department of Internal Medicine, University of Parma, Parma, Italy
Michela Marina received the Medical degree (cum laude) from the University of Parma, Parma, Italy, in 2008, where she is currently attending the specialization in endocrinology and metabolic disease.
During the postgraduate school, she is acquiring expertise in the management of endocrine-metabolic disorders, performing clinical activity for the following diseases: diabetes mellitus, with particular reference to patients with chronic complications and insulin-treated patients, obesity, dislipidemia, thyroid disorders, parathyroid disorders, adrenal disorders, pituitary disorders, gonadal disorders, and osteoporosis. Her current research interests include the field of diabetes and thyroid disease, working on quality of clinical investigator in several national and multinational trials.
Michela Marina received the Medical degree (cum laude) from the University of Parma, Parma, Italy, in 2008, where she is currently attending the specialization in endocrinology and metabolic disease.
During the postgraduate school, she is acquiring expertise in the management of endocrine-metabolic disorders, performing clinical activity for the following diseases: diabetes mellitus, with particular reference to patients with chronic complications and insulin-treated patients, obesity, dislipidemia, thyroid disorders, parathyroid disorders, adrenal disorders, pituitary disorders, gonadal disorders, and osteoporosis. Her current research interests include the field of diabetes and thyroid disease, working on quality of clinical investigator in several national and multinational trials.View more
Department of Internal Medicine, University of Parma, Parma, Italy
Ivana Zavaroni received the degree in medicine and surgery (summa cum laude) from the University of Parma, Parma, Italy, in 1973, the specialization in cardiology from the University of Siena, Siena, Italy, in 1976, the specialization in diabetes from the University of Parma, in 1978, and the specialization in nutrition from the University of Pavia, Pavia, Italy, in 1989.
She is currently a Professor of Endocrinology in the School of Medicine, University of Parma. She has been the referee of international journals, the invited speaker in national and international meetings, a coordinator of national research groups of Italian Diabetes Society, and a member of Directory Board of international scientific groups for the study of diabetes. She has authored more than 120 publications, mostly in international journals, and has also received two awards from international scientific committees. Her research interests include the insulin resistance, metabolic syndrome, and risk factors of cardiovascular disease.
Ivana Zavaroni received the degree in medicine and surgery (summa cum laude) from the University of Parma, Parma, Italy, in 1973, the specialization in cardiology from the University of Siena, Siena, Italy, in 1976, the specialization in diabetes from the University of Parma, in 1978, and the specialization in nutrition from the University of Pavia, Pavia, Italy, in 1989.
She is currently a Professor of Endocrinology in the School of Medicine, University of Parma. She has been the referee of international journals, the invited speaker in national and international meetings, a coordinator of national research groups of Italian Diabetes Society, and a member of Directory Board of international scientific groups for the study of diabetes. She has authored more than 120 publications, mostly in international journals, and has also received two awards from international scientific committees. Her research interests include the insulin resistance, metabolic syndrome, and risk factors of cardiovascular disease.View more
Department ofMechanical Engineering and Aeronautics, University of Patras, Patras, Greece
Demosthenes Polyzos was born in Karditsa, Greece, in 1958. He received the Diploma and Ph.D. degrees in mechanical engineering from the University of Patras, Patras, Greece, in 1981 and 1987, respectively.
Since 1982, he has been in the Department of Mechanical Engineering and Aeronautics, University of Patras, where he is currently a Professor. He has published more than 65 papers in scientific journals and more than 120 papers in books and international conferences. His research interests include computational mechanics and micromechanics, computational modeling in bioengineering and scientific computing.
Demosthenes Polyzos was born in Karditsa, Greece, in 1958. He received the Diploma and Ph.D. degrees in mechanical engineering from the University of Patras, Patras, Greece, in 1981 and 1987, respectively.
Since 1982, he has been in the Department of Mechanical Engineering and Aeronautics, University of Patras, where he is currently a Professor. He has published more than 65 papers in scientific journals and more than 120 papers in books and international conferences. His research interests include computational mechanics and micromechanics, computational modeling in bioengineering and scientific computing.View more
Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
Dimitrios I. Fotiadis (M’01–SM’06) was born in Ioannina, Greece, in 1961. He received the Diploma degree in chemical engineering from the Department of Chemical Engineering, National Technical University of Athens, Athens, Greece, in 1985, and the Ph.D. degree in chemical engineering and materials science from the University of Minnesota, Twin Cities, Minneapolis, in 1990.
He is currently a Professor of Biomedical Engineering in the Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece, where he is also the Director of the Unit of Medical Technology and Intelligent Information Systems and also an Associate Member of the Biomedical Research Institute. He has authored or coauthored more than 120 papers in scientific journals, 250 papers in peer-reviewed conference proceedings, and more than 20 chapters in books. He has edited 14 books. His work has received more than 800 citations. His research interests include modeling of human tissues and organs, intelligent wearable devices for automated diagnosis, and bioinformatics.
Dimitrios I. Fotiadis (M’01–SM’06) was born in Ioannina, Greece, in 1961. He received the Diploma degree in chemical engineering from the Department of Chemical Engineering, National Technical University of Athens, Athens, Greece, in 1985, and the Ph.D. degree in chemical engineering and materials science from the University of Minnesota, Twin Cities, Minneapolis, in 1990.
He is currently a Professor of Biomedical Engineering in the Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece, where he is also the Director of the Unit of Medical Technology and Intelligent Information Systems and also an Associate Member of the Biomedical Research Institute. He has authored or coauthored more than 120 papers in scientific journals, 250 papers in peer-reviewed conference proceedings, and more than 20 chapters in books. He has edited 14 books. His work has received more than 800 citations. His research interests include modeling of human tissues and organs, intelligent wearable devices for automated diagnosis, and bioinformatics.View more
