Abstract:
Chemical synaptic transmisssion involves the release of a neurotransmitter that diffuses in the extracellular space and interacts with specific receptors located on the p...Show MoreMetadata
Abstract:
Chemical synaptic transmisssion involves the release of a neurotransmitter that diffuses in the extracellular space and interacts with specific receptors located on the postsynaptic membrane. Computer simulation approaches provide fundamental tools for exploring various aspects of the synaptic transmission under different conditions. In particular, Monte Carlo methods can track the stochastic movements of neurotransmitter molecules and their interactions with other discrete molecules, the receptors. We have developed synaptic models that had a simple geometry as far as shape is concerned, but had a variable set of parameters that specified the dimensions of the structures involved in the synaptic junction. We have analyzed simulations based on these idealized models of excitatory synapses where AMPA receptors are present and the neurotransmitter involved is glutamate.
Date of Conference: 02-06 July 2012
Date Added to IEEE Xplore: 16 August 2012
ISBN Information:
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- IEEE Keywords
- Index Terms
- Neurotransmitter Diffusion ,
- Monte Carlo Simulation ,
- Extracellular Space ,
- Simulation Approach ,
- Simple Geometry ,
- Postsynaptic Membrane ,
- Discrete Molecules ,
- Rate Constant ,
- Presynaptic Terminals ,
- Synaptic Vesicles ,
- Transport Of Molecules ,
- Glutamate Release ,
- Active Zone ,
- Glutamate Transporter ,
- Postsynaptic Density ,
- Synaptic Cleft ,
- Model Geometry ,
- Kinetic Rate Constants ,
- Presence Of Transporters ,
- Postsynaptic Elements ,
- Influence Of Geometry ,
- Neuronal Elements
- Author Keywords
- AMPA ,
- synapse ,
- glutamate ,
- simulation ,
- Monte Carlo
Keywords assist with retrieval of results and provide a means to discovering other relevant content. Learn more.
- IEEE Keywords
- Index Terms
- Neurotransmitter Diffusion ,
- Monte Carlo Simulation ,
- Extracellular Space ,
- Simulation Approach ,
- Simple Geometry ,
- Postsynaptic Membrane ,
- Discrete Molecules ,
- Rate Constant ,
- Presynaptic Terminals ,
- Synaptic Vesicles ,
- Transport Of Molecules ,
- Glutamate Release ,
- Active Zone ,
- Glutamate Transporter ,
- Postsynaptic Density ,
- Synaptic Cleft ,
- Model Geometry ,
- Kinetic Rate Constants ,
- Presence Of Transporters ,
- Postsynaptic Elements ,
- Influence Of Geometry ,
- Neuronal Elements
- Author Keywords
- AMPA ,
- synapse ,
- glutamate ,
- simulation ,
- Monte Carlo