Anti-tumor activity of shark cartilage extract and related mechanisms

Shark cartilage powder and extract made in our laboratory, referred to SCE(shark carti lage extract), were used to investigate the effects of shark cartilage on the turror cell lines HeLa and BEL-7404, tumor-bearing mouse S180, reps, EAC, and several types of immune cell. The results have shown that SCE significantly inhibits tumor growth, reducing tumors rate by 60%–70%. In addition, the activi ties of natural killer (NK) cells and interleukin-activated kill er (LAK) cells to the target cells Yac−1 and P815 are increased after treatrrent with SCE, suggesting a possible mechanism for increasing tumor monitoring and inhibition activities.