Abstract:
Interfacial fibrosis is known to dramatically decrease the lifespan, stability, and function of biomedical implants and bone-anchored prosthetics. Bioactive coatings aime...Show MoreMetadata
Abstract:
Interfacial fibrosis is known to dramatically decrease the lifespan, stability, and function of biomedical implants and bone-anchored prosthetics. Bioactive coatings aimed at mitigating fibrous adhesions are one of the approaches to alleviate the problem. In this paper, we are developing a bioactive coating based upon a magnetoelastic (ME) material that vibrates in response to an ac magnetic field. In order to establish these coatings for this purpose, the ME material was first rendered bioactive through the sequential addition of polyurethane and chitosan thin films. Indirect live/dead assays were performed showing increased cell viability for polyurethane and chitosan-coated sensors compared to the uncoated controls. Direct adhesion experiments were performed to test the response of fibroblasts cultured on static and vibrated ME materials. Results showed cells adherent to static but not vibrated coatings. Detached cells showed no viability loss compared to controls. The finding that submicrometer ME vibrations can prevent cell adhesion in vitro without inducing cell death suggests the potential of these coatings to effectively control interfacial fibrosis. Future work will address the effect of vibrations on cell morphology and local gene expression in vitro, as well as fibrous tissue formation in vivo.
Published in: IEEE Transactions on Biomedical Engineering ( Volume: 58, Issue: 3, March 2011)
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Eli Vlaisavljevich received the B.S. degree in biomedical engineering from Michigan Technological University, Houghton, in June 2010. He is currently working in the Image-Guided Ultrasound Therapy Laboratory at the University of Michigan, where plans to pursue a Ph.D. degree in biomedical engineering.
He has presented his work at the 2008 Biomedical Engineering Society Conference, the 2009 Design of Medical Devices Confere...Show More
Eli Vlaisavljevich received the B.S. degree in biomedical engineering from Michigan Technological University, Houghton, in June 2010. He is currently working in the Image-Guided Ultrasound Therapy Laboratory at the University of Michigan, where plans to pursue a Ph.D. degree in biomedical engineering.
He has presented his work at the 2008 Biomedical Engineering Society Conference, the 2009 Design of Medical Devices Confere...View more
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Logan P. Janka is pursuing the B.S. degrees in biomedical engineering and mechanical engineering from Michigan Technological University, Houghton.
He has presented his work at the 2008 Design of Medical Devices Conference and the 2008 Biomedical Engineering Society Annual meeting. He has received undergraduate funding through the Michigan Tech Summer Undergraduate Research Fellowship and a Biotech Travel Grant. He is curre...Show More
Logan P. Janka is pursuing the B.S. degrees in biomedical engineering and mechanical engineering from Michigan Technological University, Houghton.
He has presented his work at the 2008 Design of Medical Devices Conference and the 2008 Biomedical Engineering Society Annual meeting. He has received undergraduate funding through the Michigan Tech Summer Undergraduate Research Fellowship and a Biotech Travel Grant. He is curre...View more
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Keat Ghee Ong received the B.S., M.S., and Ph.D. degrees in electrical engineering from the University of Kentucky, Lexington, in 1997, 1998, and 2000, respectively.
He was a Research Associate at the Pennsylvania State University PA, in 2001, and the Chief Scientist at Sentech/KMG2 Sensors Corporation, State College, PA, until 2006. He is currently an Assistant Professor in the Department of Biomedical Engineering, Michig...Show More
Keat Ghee Ong received the B.S., M.S., and Ph.D. degrees in electrical engineering from the University of Kentucky, Lexington, in 1997, 1998, and 2000, respectively.
He was a Research Associate at the Pennsylvania State University PA, in 2001, and the Chief Scientist at Sentech/KMG2 Sensors Corporation, State College, PA, until 2006. He is currently an Assistant Professor in the Department of Biomedical Engineering, Michig...View more
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Rupak M. Rajachar received the B.S., M.S., and Ph.D. degrees in materials sciences and engineering and biomedical engineering from the University of Michigan, Dearborn, in 1994, 1998, and 2003, respectively.
From 2003 to 2006, he was a Senior Research Fellow at the University of Washington Engineered Biomaterials Research Center, Seattle. He is currently an Assistant Professor in the Department of Biomedical Engineering, M...Show More
Rupak M. Rajachar received the B.S., M.S., and Ph.D. degrees in materials sciences and engineering and biomedical engineering from the University of Michigan, Dearborn, in 1994, 1998, and 2003, respectively.
From 2003 to 2006, he was a Senior Research Fellow at the University of Washington Engineered Biomaterials Research Center, Seattle. He is currently an Assistant Professor in the Department of Biomedical Engineering, M...View more
Contents Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Eli Vlaisavljevich received the B.S. degree in biomedical engineering from Michigan Technological University, Houghton, in June 2010. He is currently working in the Image-Guided Ultrasound Therapy Laboratory at the University of Michigan, where plans to pursue a Ph.D. degree in biomedical engineering.
He has presented his work at the 2008 Biomedical Engineering Society Conference, the 2009 Design of Medical Devices Conference, and the 2009 American Society of Mechanical Engineers Bioengineering Conference. In addition, a Michigan Tech Summer Undergraduate Research Fellowship and a Biotech Travel grant have funded his undergraduate research. His main research interest includes the development of “environmentally active” biomaterials.
Mr. Vlaisavljevich was awarded a Goldwater Scholarship, named Scholar of the Department of Biomedical Engineering, in 2009, and received the Provost's award for the Scholarship.
Eli Vlaisavljevich received the B.S. degree in biomedical engineering from Michigan Technological University, Houghton, in June 2010. He is currently working in the Image-Guided Ultrasound Therapy Laboratory at the University of Michigan, where plans to pursue a Ph.D. degree in biomedical engineering.
He has presented his work at the 2008 Biomedical Engineering Society Conference, the 2009 Design of Medical Devices Conference, and the 2009 American Society of Mechanical Engineers Bioengineering Conference. In addition, a Michigan Tech Summer Undergraduate Research Fellowship and a Biotech Travel grant have funded his undergraduate research. His main research interest includes the development of “environmentally active” biomaterials.
Mr. Vlaisavljevich was awarded a Goldwater Scholarship, named Scholar of the Department of Biomedical Engineering, in 2009, and received the Provost's award for the Scholarship.View more
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Logan P. Janka is pursuing the B.S. degrees in biomedical engineering and mechanical engineering from Michigan Technological University, Houghton.
He has presented his work at the 2008 Design of Medical Devices Conference and the 2008 Biomedical Engineering Society Annual meeting. He has received undergraduate funding through the Michigan Tech Summer Undergraduate Research Fellowship and a Biotech Travel Grant. He is currently enrolled in a cooperative education program with Kimberly-Clark Corporation, Neenah, WI. His research interest includes the design and manufacturing of medical devices.
Logan P. Janka is pursuing the B.S. degrees in biomedical engineering and mechanical engineering from Michigan Technological University, Houghton.
He has presented his work at the 2008 Design of Medical Devices Conference and the 2008 Biomedical Engineering Society Annual meeting. He has received undergraduate funding through the Michigan Tech Summer Undergraduate Research Fellowship and a Biotech Travel Grant. He is currently enrolled in a cooperative education program with Kimberly-Clark Corporation, Neenah, WI. His research interest includes the design and manufacturing of medical devices.View more
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Keat Ghee Ong received the B.S., M.S., and Ph.D. degrees in electrical engineering from the University of Kentucky, Lexington, in 1997, 1998, and 2000, respectively.
He was a Research Associate at the Pennsylvania State University PA, in 2001, and the Chief Scientist at Sentech/KMG2 Sensors Corporation, State College, PA, until 2006. He is currently an Assistant Professor in the Department of Biomedical Engineering, Michigan Technological University, Houghton. He is the author or coauthor of more than 80 publications in archival journals and conference proceedings, and multiple patents, and is the author of three book chapters. His areas of expertise include implantable biosensors, and biological sensing materials and devices, magnetism, RF, and acoustic-based sensors, magnetoelastic materials, nanoporous metal oxides and carbon nanotubes, and measurement technique and instrument automation.
Dr. Ong is the North American Editor of Sensor Letters.
Keat Ghee Ong received the B.S., M.S., and Ph.D. degrees in electrical engineering from the University of Kentucky, Lexington, in 1997, 1998, and 2000, respectively.
He was a Research Associate at the Pennsylvania State University PA, in 2001, and the Chief Scientist at Sentech/KMG2 Sensors Corporation, State College, PA, until 2006. He is currently an Assistant Professor in the Department of Biomedical Engineering, Michigan Technological University, Houghton. He is the author or coauthor of more than 80 publications in archival journals and conference proceedings, and multiple patents, and is the author of three book chapters. His areas of expertise include implantable biosensors, and biological sensing materials and devices, magnetism, RF, and acoustic-based sensors, magnetoelastic materials, nanoporous metal oxides and carbon nanotubes, and measurement technique and instrument automation.
Dr. Ong is the North American Editor of Sensor Letters.View more
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA
Rupak M. Rajachar received the B.S., M.S., and Ph.D. degrees in materials sciences and engineering and biomedical engineering from the University of Michigan, Dearborn, in 1994, 1998, and 2003, respectively.
From 2003 to 2006, he was a Senior Research Fellow at the University of Washington Engineered Biomaterials Research Center, Seattle. He is currently an Assistant Professor in the Department of Biomedical Engineering, Michigan Technological University, Houghton. He is also engaged in the design and formulation of composite materials for hard and soft tissue engineering. He is the author or coauthor of more than 30 publications in archival journals and conference proceedings. His areas of expertise include biomimetic materials, cell and tissue mechanics, and the host response to implantable materials.
Rupak M. Rajachar received the B.S., M.S., and Ph.D. degrees in materials sciences and engineering and biomedical engineering from the University of Michigan, Dearborn, in 1994, 1998, and 2003, respectively.
From 2003 to 2006, he was a Senior Research Fellow at the University of Washington Engineered Biomaterials Research Center, Seattle. He is currently an Assistant Professor in the Department of Biomedical Engineering, Michigan Technological University, Houghton. He is also engaged in the design and formulation of composite materials for hard and soft tissue engineering. He is the author or coauthor of more than 30 publications in archival journals and conference proceedings. His areas of expertise include biomimetic materials, cell and tissue mechanics, and the host response to implantable materials.View more
