Model-based estimation of cardiac output and total peripheral resistance | IEEE Conference Publication | IEEE Xplore

Model-based estimation of cardiac output and total peripheral resistance


Abstract:

We describe a novel model-based approach to estimate cardiac output (CO) and total peripheral resistance (TPR) continuously from peripheral arterial blood pressure (ABP) ...Show More

Abstract:

We describe a novel model-based approach to estimate cardiac output (CO) and total peripheral resistance (TPR) continuously from peripheral arterial blood pressure (ABP) waveforms. Our method exploits the intra-beat and inter-beat variability in ABP to estimate the lumped time constant of a beat-to-beat averaged Windkessel model of the arterial tree, from which we obtain an uncalibrated estimate of CO. To estimate absolute CO, we determine the lumped arterial compliance using calibration data, and assuming either constant or state-dependent compliance. We applied our method to a porcine data set in which stroke volume was measured with an ultrasonic flowmeter. We obtain root-mean-square normalized errors of 11-13% across all pigs, lower than those obtained on the same data set using various other estimation methods. The CO estimates, and TPR estimates derived from them track intravenous drug infusions quite closely.
Date of Conference: 30 September 2007 - 03 October 2007
Date Added to IEEE Xplore: 09 January 2009
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Conference Location: Durham, NC, USA

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