Loading [MathJax]/extensions/MathMenu.js
An immune algorithm with hyper-macromutations for the Dill's 2D hydrophobic-hydrophilic model | IEEE Conference Publication | IEEE Xplore

An immune algorithm with hyper-macromutations for the Dill's 2D hydrophobic-hydrophilic model


Abstract:

This paper presents an immune algorithm (IA) based on clonal selection principle using a mutation operator, the hypermacromutation, and an aging process to tackle the pro...Show More

Abstract:

This paper presents an immune algorithm (IA) based on clonal selection principle using a mutation operator, the hypermacromutation, and an aging process to tackle the protein structure prediction problem (PSP) in the 2D hydrophobic-hydrophilic model. The IA presented has only three parameters. To correctly set these parameters we compute the parameter surfaces, the 3D plots of IA success rate in function of the cloning parameter and the maximum age allowed to each B cell. The parameter surfaces show that hypermacromutation and aging operators are key features for generating diversity and searching more properly the funnel landscape of the PSP problem. Experiments show that the immune algorithm we propose is very competitive with the state-of-art algorithms for the PSP.
Date of Conference: 19-23 June 2004
Date Added to IEEE Xplore: 03 September 2004
Print ISBN:0-7803-8515-2
Conference Location: Portland, OR, USA

Contact IEEE to Subscribe

References

References is not available for this document.