I. Introduction
Quantum annealing algorithms are drawing increasing attention [1], [2], [3], [4], [5], [6], [7]. They have shown commercial potential in solving some instances of combinatorial optimization problems, such as set covering [8], fault diagnosis [9], satisfiability (SAT) [10], [11], prime factorization [12], and computer vision [13]. As shown in the upper part of Fig. 1, to solve general optimization problems on quantum annealing machines, the problems are firstly mapped into an energy-like format called Quadratic Unconstrained Binary Optimization (QUBO) problems [14], [15] (we refer to this process as qubonization in this paper), and then topologically legalized [16], [17] to the quantum annealing machine [18], [19], [20], [21].