Development of melanoma growth models for assessment of microwave-based diagnostic tools at different stages of tumor progression.
Impact Statement:Take-Home Messages •The objective of this study is to assess the ability of microwave-based tools to diagnose melanoma at all stages of tumor growth progression. •To acco...Show More
Abstract:
Malignant melanoma, the aggressive form of skin cancer, progresses via radial and vertical growth. The aim of this study is to assess the feasibility of microwave-based d...Show MoreMetadata
Impact Statement:
Take-Home Messages •The objective of this study is to assess the ability of microwave-based tools to diagnose melanoma at all stages of tumor growth progression. •To accomplish this, oil-in-gelatin phantom models, based on developed mathematical models of radial and vertical growth of melanoma, including dielectric properties of all tissues under consideration for the microwave frequency range, were fabricated. •The developed phantoms were characterized using Keysight slim-form open-ended coaxial probe (N1501A) by methodically sampling dielectric values at a range of points across the mimicked skin surface. •The results show that the microwave spectroscopy not only demonstrates the ability to discern between the tumorous and healthy skin, but that it can also differentiate between tumors of varying stages of vertical growth that cannot be perceived visually from the skin surface.
Abstract:
Malignant melanoma, the aggressive form of skin cancer, progresses via radial and vertical growth. The aim of this study is to assess the feasibility of microwave-based diagnosis of melanoma at different stages of tumor progression. To this end, we used the physiological data for melanoma progression to develop a theoretical model of melanoma growth, followed by the oil-in-gelatin based tissue phantoms, which aim to mimic the dielectric behavior of the tissues under consideration. The phantoms are then dielectrically characterized using a slim-form open-ended coaxial probe by systematically sampling dielectric values across the mimicked skin surfaces at a range of points over the 0.5 – 26.5 GHz frequency range. The resulting observations revealed that the microwave spectroscopy exhibits the capability not only to distinguish between healthy and malignant skin, but also differentiate between tumors at different stages of vertical growth, which may not be visually discernible from the sk...
Development of melanoma growth models for assessment of microwave-based diagnostic tools at different stages of tumor progression.
Published in: IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology ( Volume: 8, Issue: 3, September 2024)