Evaluation of Pharmacological Treatment in Acute Osteo Arthrosis Model by Means of Kinematic Analysis and Pain Threshold

The proposed study proves the option to have a different treatment displayed on quantitative and qualitative parameters of kinematics and pain tests, by experiments with mice groups during walk and mobility analysis with kinematics parameters and pain sensation using Von Frey filaments in acute osteoarthritis knee (AOAK) model. This would allow us to have enough information to recommend or not recommend a new based treatment that can be compared to another successful treatment for osteoarthritis. Clinical Relevance — Therefore, with this study it is proposed to be able to analyze different compounds from opioids, steroids, and non-steroid anti-inflammatories (NSAIDs) like cannabinoid components, avoiding with that the dependance pathology and renal damage in patients treated with one of this kind of common treatments and thus be able to determine their viability on a in vivo model to recommend their study in instances closer to a clinical model.