Abstract:
Cell microinjection plays an important role in biological and medical fields. As compared with manual cell microinjection and position-based robotic cell microinjection, ...Show MoreMetadata
Abstract:
Cell microinjection plays an important role in biological and medical fields. As compared with manual cell microinjection and position-based robotic cell microinjection, force-assisted robotic cell microinjection can improve the success rate and survival rate of the injected cells. In this paper, a novel force-sensing cell microinjector is proposed with a piezoresistive force sensor embedded in soft-material-based flexure mechanism. The soft flexures act as fixed-guided beams, which are introduced to achieve the force measurement with high sensitivity in pure one-degree-of-freedom direction. The microinjector is developed by considering the installation and replacement issues of the micropipette and the connection between the micropipette and the tube of compressed air. Four different prototypes of the cell microinjector with force sensor are fabricated, calibrated, and compared. Results show that the resolution and measurement ranges of an embedded force sensor are 0.65 mN and 16.5 mN, respectively. Experimental study on microinjection of crab eggs is conducted to validate the performance of the fabricated microinjector in practice.
Published in: IEEE Sensors Journal ( Volume: 19, Issue: 15, 01 August 2019)
Funding Agency:
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Department of Electromechanical Engineering, University of Macau, Macau, China
Yuzhang Wei received the B.S. degree in mechatronics engineering from the Harbin Institute of Technology, Harbin, Heilongjiang, China, in 2014, and the M.S. degree in electromechanical engineering from the University of Macau, Macao, China, in 2017, where he is currently pursuing the Ph.D. degree. His research interests include design and fabrication of microsensors.
Yuzhang Wei received the B.S. degree in mechatronics engineering from the Harbin Institute of Technology, Harbin, Heilongjiang, China, in 2014, and the M.S. degree in electromechanical engineering from the University of Macau, Macao, China, in 2017, where he is currently pursuing the Ph.D. degree. His research interests include design and fabrication of microsensors.View more

Department of Electromechanical Engineering, University of Macau, Macau, China
Qingsong Xu (M’09–SM’15) received the B.S. (Hons.) degree in mechatronics engineering from the Beijing Institute of Technology, Beijing, China, in 2002, and the M.S. and Ph.D. degrees in electromechanical engineering from the University of Macau, Macao, China, in 2004 and 2008, respectively.
He was a Visiting Scholar with the University of California at Los Angeles, Los Angeles, CA, USA, RMIT University, Melbourne, VIC, Au...Show More
Qingsong Xu (M’09–SM’15) received the B.S. (Hons.) degree in mechatronics engineering from the Beijing Institute of Technology, Beijing, China, in 2002, and the M.S. and Ph.D. degrees in electromechanical engineering from the University of Macau, Macao, China, in 2004 and 2008, respectively.
He was a Visiting Scholar with the University of California at Los Angeles, Los Angeles, CA, USA, RMIT University, Melbourne, VIC, Au...View more

Department of Electromechanical Engineering, University of Macau, Macau, China
Yuzhang Wei received the B.S. degree in mechatronics engineering from the Harbin Institute of Technology, Harbin, Heilongjiang, China, in 2014, and the M.S. degree in electromechanical engineering from the University of Macau, Macao, China, in 2017, where he is currently pursuing the Ph.D. degree. His research interests include design and fabrication of microsensors.
Yuzhang Wei received the B.S. degree in mechatronics engineering from the Harbin Institute of Technology, Harbin, Heilongjiang, China, in 2014, and the M.S. degree in electromechanical engineering from the University of Macau, Macao, China, in 2017, where he is currently pursuing the Ph.D. degree. His research interests include design and fabrication of microsensors.View more

Department of Electromechanical Engineering, University of Macau, Macau, China
Qingsong Xu (M’09–SM’15) received the B.S. (Hons.) degree in mechatronics engineering from the Beijing Institute of Technology, Beijing, China, in 2002, and the M.S. and Ph.D. degrees in electromechanical engineering from the University of Macau, Macao, China, in 2004 and 2008, respectively.
He was a Visiting Scholar with the University of California at Los Angeles, Los Angeles, CA, USA, RMIT University, Melbourne, VIC, Australia, the National University of Singapore, Singapore, and the Swiss Federal Institute of Technology, Zurich, Switzerland. He is currently an Associate Professor of Electromechanical Engineering with the University of Macau, where he directs the Smart and Micro/Nano Systems Laboratory. His current research interests include microsystem/nanosystem, micromechatronics/nanomechatronics, robotics and automation, smart materials and structures, and computational intelligence.
Dr. Xu is a member of the American Society of Mechanical Engineers (ASME). He is a Technical Editor of the IEEE/ASME Transactions on Mechatronics and an Associate Editor of the IEEE Transactions on Automation Science and Engineering, the IEEE Robotics and Automation Letters, and the International Journal of Advanced Robotic Systems. He also serves on the editorial boards of six international journals.
Qingsong Xu (M’09–SM’15) received the B.S. (Hons.) degree in mechatronics engineering from the Beijing Institute of Technology, Beijing, China, in 2002, and the M.S. and Ph.D. degrees in electromechanical engineering from the University of Macau, Macao, China, in 2004 and 2008, respectively.
He was a Visiting Scholar with the University of California at Los Angeles, Los Angeles, CA, USA, RMIT University, Melbourne, VIC, Australia, the National University of Singapore, Singapore, and the Swiss Federal Institute of Technology, Zurich, Switzerland. He is currently an Associate Professor of Electromechanical Engineering with the University of Macau, where he directs the Smart and Micro/Nano Systems Laboratory. His current research interests include microsystem/nanosystem, micromechatronics/nanomechatronics, robotics and automation, smart materials and structures, and computational intelligence.
Dr. Xu is a member of the American Society of Mechanical Engineers (ASME). He is a Technical Editor of the IEEE/ASME Transactions on Mechatronics and an Associate Editor of the IEEE Transactions on Automation Science and Engineering, the IEEE Robotics and Automation Letters, and the International Journal of Advanced Robotic Systems. He also serves on the editorial boards of six international journals.View more