Abstract:
High Intensity Focused Ultrasound (HIFU) is a very promising technology for a non-invasive treatment of several pathologies, especially in oncology. However, optimizing t...Show MoreMetadata
Abstract:
High Intensity Focused Ultrasound (HIFU) is a very promising technology for a non-invasive treatment of several pathologies, especially in oncology. However, optimizing the stimulation parameters for better tuning the induced lethal effects (thermal and/or mechanical) in the targeted area is not trivial and it has not been achieved yet. The aim of this study is to present the results of a combined analysis of temperature, acoustic cavitation and lesion geometry induced in ex vivo tissues during HIFU procedures by varying power, sonication time and duty cycle. Temperature rise was analyzed using a thin wire thermocouple embedded in the sonicated tissue; stable and inertial cavitation were measured using a passive cavitation detector (PCD), and lesion volume was assessed using both ultrasound imaging and optical visualization. The obtained results may represent an important guideline for clinical treatments, providing useful nformation for better tuning HIFU operational parameters to induce a desired type of ablation (i.e. thermal, mechanical or a combination of both).
Published in: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Date of Conference: 18-21 July 2018
Date Added to IEEE Xplore: 28 October 2018
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ISSN Information:
PubMed ID: 30441631