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A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management | IEEE Journals & Magazine | IEEE Xplore

A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management


Abstract:

Although closed-loop deep brain stimulation (DBS) promises treatment of many neurological disorders, an implantable system-on-chip (SoC) implementing an effective closed-...Show More

Abstract:

Although closed-loop deep brain stimulation (DBS) promises treatment of many neurological disorders, an implantable system-on-chip (SoC) implementing an effective closed-loop DBS algorithm has not been demonstrated. This work introduces a logarithmic, closed-loop DBS system that detects and processes low-frequency brain field signals to control and adapt stimulation currents. The system records and processes neural signals with four low-noise neural amplifier (LNA) channels, a multiplexed logarithmic ADC, and two high-pass and two low-pass digital logarithmic filters. Logarithmic processing saves power and achieves high dynamic range. A logarithmic domain digital signal processor (DSP) and PI-controller controls eight current stimulator channels and enables closed-loop stimulation. An RF transceiver, a clock generator, and a power harvester are also included in the system to achieve a complete implantable SoC. The 4 mm2 180 nm CMOS prototype consumes a total of 468 μW for recording and processing neural signals, for stimulation, and for two-way wireless communication.
Published in: IEEE Journal of Solid-State Circuits ( Volume: 49, Issue: 10, October 2014)
Page(s): 2213 - 2227
Date of Publication: 28 August 2014

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