Abstract:
In this work, a surface plasmon resonance (SPR) sensor based on plastic spoon-shaped waveguides and plastic optical fibers (POFs) was tested in a novel experimental confi...Show MoreMetadata
Abstract:
In this work, a surface plasmon resonance (SPR) sensor based on plastic spoon-shaped waveguides and plastic optical fibers (POFs) was tested in a novel experimental configuration. The latter was achieved by launching the light from the bowl of the spoon and collecting it from its neck. First, the sensor was optically tested, thus obtaining a 55% improvement in terms of bulk sensitivity with respect to the better spoon-shaped sensor configuration presented in the literature. Then, binding tests were performed by functionalizing the neck of the SPR spoon-shaped probe with an anti-IgG-based recognition layer. The SPR biosensor tested via the novel experimental configuration was tested in IgG detection, denoting an ultralow limit of detection (LOD) equal to about 60 fM. Moreover, by keeping the measurement setup unchanged and by a 180° rotation of the biosensor chip position, it was possible to achieve an LOD of about 50 pM. Therefore, the proposed sensing approach can be used to span a higher concentration range, thus paving the way to the possibility to detect the IgG in an ultrawide concentration range over four orders of magnitude via a simple rotation of the chip. These findings highlight the adaptability of the spoon-shaped SPR sensor to provide tailored sensitivity through the variation of the interrogation configuration, thus broadening its potential use for various point-of-care test (POCT) applications.
Published in: IEEE Transactions on Instrumentation and Measurement ( Volume: 74)
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Debora Verolla was born in Aversa, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, in 2024.
Her current research interests include the design and fabrication of optical sensors and optoelectronics devices.
Debora Verolla was born in Aversa, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, in 2024.
Her current research interests include the design and fabrication of optical sensors and optoelectronics devices.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Francesco Arcadio was born in Italy, in 1991. He received the master’s degree in electronic engineering and the Ph.D. degree in industrial and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2018 and 2021, respectively.
He is currently a Post-Doctoral Researcher with the University of Campania Luigi Vanvitelli. He is also a Co-Founder of the spin-off company MORESENSE, Milan, Ita...Show More
Francesco Arcadio was born in Italy, in 1991. He received the master’s degree in electronic engineering and the Ph.D. degree in industrial and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2018 and 2021, respectively.
He is currently a Post-Doctoral Researcher with the University of Campania Luigi Vanvitelli. He is also a Co-Founder of the spin-off company MORESENSE, Milan, Ita...View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Luigi Zeni received the master’s (summa cum laude) degree in electronic engineering from the University of Naples, Naples, Italy, in 1988, and the Ph.D. degree in electronics and computer science from the University of Naples Federico II, Naples, in 1992.
He is Full Professor of Electronics with the University of Campania L. Vanvitelli, Aversa, Italy, and the President of the Research Consortium on Advanced Remote Sensing ...Show More
Luigi Zeni received the master’s (summa cum laude) degree in electronic engineering from the University of Naples, Naples, Italy, in 1988, and the Ph.D. degree in electronics and computer science from the University of Naples Federico II, Naples, in 1992.
He is Full Professor of Electronics with the University of Campania L. Vanvitelli, Aversa, Italy, and the President of the Research Consortium on Advanced Remote Sensing ...View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Chiara Marzano was born in Marcianise, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2024, where she is currently pursuing the Ph.D. degree in industrial and information engineering.
Her research interests include the design and fabrication of optical sensors and optoelectronics devices.
Chiara Marzano was born in Marcianise, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2024, where she is currently pursuing the Ph.D. degree in industrial and information engineering.
Her research interests include the design and fabrication of optical sensors and optoelectronics devices.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Mimimorena Seggio was born in Catania in 1988. She received the Ph.D. in chemical sciences from the Photochemistry Laboratory, University of Catania, Catania, in 2021.
She was an Assistant Professor at the University of Verona, Verona, Italy, until September 2024. Since October 2024, she is a Research Fellow at the University of Campania L. Vanvitelli, Italy. Her current research interests focus on the development and char...Show More
Mimimorena Seggio was born in Catania in 1988. She received the Ph.D. in chemical sciences from the Photochemistry Laboratory, University of Catania, Catania, in 2021.
She was an Assistant Professor at the University of Verona, Verona, Italy, until September 2024. Since October 2024, she is a Research Fellow at the University of Campania L. Vanvitelli, Italy. Her current research interests focus on the development and char...View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Ernesto Nappi was born in Italy, in 1985. He received the bachelor’s degree in computer and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2010, and the master’s degree in computer and information engineering from the University of Naples Federico II, Naples, Italy, in 2013. He is currently pursuing the Ph.D. degree in industrial and information engineering with the University ...Show More
Ernesto Nappi was born in Italy, in 1985. He received the bachelor’s degree in computer and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2010, and the master’s degree in computer and information engineering from the University of Naples Federico II, Naples, Italy, in 2013. He is currently pursuing the Ph.D. degree in industrial and information engineering with the University ...View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Nunzio Cennamo (Member, IEEE) was born in Naples, Italy, in 1975. He received the master’s and Ph.D. degrees in electronic engineering from the Second University of Naples, Naples, in 2002 and 2005, respectively.
He is currently a Full Professor of electronics with the Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy. He is also a Co-Founder of the spin-off MORESENSE srl, Milan, Italy. He h...Show More
Nunzio Cennamo (Member, IEEE) was born in Naples, Italy, in 1975. He received the master’s and Ph.D. degrees in electronic engineering from the Second University of Naples, Naples, in 2002 and 2005, respectively.
He is currently a Full Professor of electronics with the Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy. He is also a Co-Founder of the spin-off MORESENSE srl, Milan, Italy. He h...View more
Contents Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Debora Verolla was born in Aversa, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, in 2024.
Her current research interests include the design and fabrication of optical sensors and optoelectronics devices.
Debora Verolla was born in Aversa, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, in 2024.
Her current research interests include the design and fabrication of optical sensors and optoelectronics devices.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Francesco Arcadio was born in Italy, in 1991. He received the master’s degree in electronic engineering and the Ph.D. degree in industrial and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2018 and 2021, respectively.
He is currently a Post-Doctoral Researcher with the University of Campania Luigi Vanvitelli. He is also a Co-Founder of the spin-off company MORESENSE, Milan, Italy. His research interests include the design and fabrication of optical sensors and biosensors.
Francesco Arcadio was born in Italy, in 1991. He received the master’s degree in electronic engineering and the Ph.D. degree in industrial and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2018 and 2021, respectively.
He is currently a Post-Doctoral Researcher with the University of Campania Luigi Vanvitelli. He is also a Co-Founder of the spin-off company MORESENSE, Milan, Italy. His research interests include the design and fabrication of optical sensors and biosensors.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Luigi Zeni received the master’s (summa cum laude) degree in electronic engineering from the University of Naples, Naples, Italy, in 1988, and the Ph.D. degree in electronics and computer science from the University of Naples Federico II, Naples, in 1992.
He is Full Professor of Electronics with the University of Campania L. Vanvitelli, Aversa, Italy, and the President of the Research Consortium on Advanced Remote Sensing Systems—CO.RI.S.T.A. (www.corista.eu). He was the Vice-Director of the Department of Information Engineering from 2001 to 2012. He was a Visiting Scientist with TU-DELFT, Delft, The Netherlands. He has been the National Coordinator of PRIN Projects, a Scientific Coordinator of research contracts with public and private institutions and responsible for projects funded within the Seventh FP of the EU. He is also the Founder of the spin-off company Optosensing, dealing with structural and environmental monitoring by optical fiber sensors. He is the author of more than 140 articles in international journals, 150 publications at international conferences, and 12 patents. His research interests include optical fiber sensors for distributed measurements of deformation and temperature, optoelectronic integrated sensors, and biosensors.
Dr. Zeni was a Management Committee Member of the COST 299 “Optical Fibers for New Challenges Facing the Information Society” and the COST TD1001 “Novel and Reliable Optical Fiber Sensor Systems for Future Security and Safety Applications.”
Luigi Zeni received the master’s (summa cum laude) degree in electronic engineering from the University of Naples, Naples, Italy, in 1988, and the Ph.D. degree in electronics and computer science from the University of Naples Federico II, Naples, in 1992.
He is Full Professor of Electronics with the University of Campania L. Vanvitelli, Aversa, Italy, and the President of the Research Consortium on Advanced Remote Sensing Systems—CO.RI.S.T.A. (www.corista.eu). He was the Vice-Director of the Department of Information Engineering from 2001 to 2012. He was a Visiting Scientist with TU-DELFT, Delft, The Netherlands. He has been the National Coordinator of PRIN Projects, a Scientific Coordinator of research contracts with public and private institutions and responsible for projects funded within the Seventh FP of the EU. He is also the Founder of the spin-off company Optosensing, dealing with structural and environmental monitoring by optical fiber sensors. He is the author of more than 140 articles in international journals, 150 publications at international conferences, and 12 patents. His research interests include optical fiber sensors for distributed measurements of deformation and temperature, optoelectronic integrated sensors, and biosensors.
Dr. Zeni was a Management Committee Member of the COST 299 “Optical Fibers for New Challenges Facing the Information Society” and the COST TD1001 “Novel and Reliable Optical Fiber Sensor Systems for Future Security and Safety Applications.”View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Chiara Marzano was born in Marcianise, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2024, where she is currently pursuing the Ph.D. degree in industrial and information engineering.
Her research interests include the design and fabrication of optical sensors and optoelectronics devices.
Chiara Marzano was born in Marcianise, Italy. She received the master’s degree in electronic engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2024, where she is currently pursuing the Ph.D. degree in industrial and information engineering.
Her research interests include the design and fabrication of optical sensors and optoelectronics devices.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Mimimorena Seggio was born in Catania in 1988. She received the Ph.D. in chemical sciences from the Photochemistry Laboratory, University of Catania, Catania, in 2021.
She was an Assistant Professor at the University of Verona, Verona, Italy, until September 2024. Since October 2024, she is a Research Fellow at the University of Campania L. Vanvitelli, Italy. Her current research interests focus on the development and characterization of optical biosensors and chemical sensors applied to environmental and biomedical monitoring.
Mimimorena Seggio was born in Catania in 1988. She received the Ph.D. in chemical sciences from the Photochemistry Laboratory, University of Catania, Catania, in 2021.
She was an Assistant Professor at the University of Verona, Verona, Italy, until September 2024. Since October 2024, she is a Research Fellow at the University of Campania L. Vanvitelli, Italy. Her current research interests focus on the development and characterization of optical biosensors and chemical sensors applied to environmental and biomedical monitoring.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Ernesto Nappi was born in Italy, in 1985. He received the bachelor’s degree in computer and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2010, and the master’s degree in computer and information engineering from the University of Naples Federico II, Naples, Italy, in 2013. He is currently pursuing the Ph.D. degree in industrial and information engineering with the University of Campania Luigi Vanvitelli.
He was a Software Engineer in major companies, with extensive experience. He is the CEO and Founder of the Italian start-up Bitify srl, Crispano, Italy. His research interests include the design and development of optical sensors and biosensors for point-of-care (POC) applications.
Ernesto Nappi was born in Italy, in 1985. He received the bachelor’s degree in computer and information engineering from the University of Campania Luigi Vanvitelli, Aversa, Italy, in 2010, and the master’s degree in computer and information engineering from the University of Naples Federico II, Naples, Italy, in 2013. He is currently pursuing the Ph.D. degree in industrial and information engineering with the University of Campania Luigi Vanvitelli.
He was a Software Engineer in major companies, with extensive experience. He is the CEO and Founder of the Italian start-up Bitify srl, Crispano, Italy. His research interests include the design and development of optical sensors and biosensors for point-of-care (POC) applications.View more
Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy
Nunzio Cennamo (Member, IEEE) was born in Naples, Italy, in 1975. He received the master’s and Ph.D. degrees in electronic engineering from the Second University of Naples, Naples, in 2002 and 2005, respectively.
He is currently a Full Professor of electronics with the Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy. He is also a Co-Founder of the spin-off MORESENSE srl, Milan, Italy. He has authored more than 210 international journal articles and conference papers, and 12 patents. His research interests include the design and fabrication of optical sensors, chemical sensors, biosensors, and optoelectronic devices.
Prof. Cennamo is a reviewer for several technical journals, the General Chair and a member of the scientific committee of several international conferences, and an associate editor of several international journals.
Nunzio Cennamo (Member, IEEE) was born in Naples, Italy, in 1975. He received the master’s and Ph.D. degrees in electronic engineering from the Second University of Naples, Naples, in 2002 and 2005, respectively.
He is currently a Full Professor of electronics with the Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy. He is also a Co-Founder of the spin-off MORESENSE srl, Milan, Italy. He has authored more than 210 international journal articles and conference papers, and 12 patents. His research interests include the design and fabrication of optical sensors, chemical sensors, biosensors, and optoelectronic devices.
Prof. Cennamo is a reviewer for several technical journals, the General Chair and a member of the scientific committee of several international conferences, and an associate editor of several international journals.View more
