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Evaluating Different Fluoride Glass Fibers and Topological Insulator BSTS Impact on Cortisol Sensing Utilizing SPR Sensor | IEEE Journals & Magazine | IEEE Xplore

Evaluating Different Fluoride Glass Fibers and Topological Insulator BSTS Impact on Cortisol Sensing Utilizing SPR Sensor


Abstract:

The effects of different types of fluoride glass core fibers, from three main groups of fluorozirconate (ZrF4-based), fluoroaluminate (AlF3-based), and fluoroindate (InF3...Show More

Abstract:

The effects of different types of fluoride glass core fibers, from three main groups of fluorozirconate (ZrF4-based), fluoroaluminate (AlF3-based), and fluoroindate (InF3-based) fibers, were investigated in sensing salivary cortisol utilizing surface plasmon resonance (SPR) sensors. These sensors comprised multiple layers, including fluoride glass core, metal (Ag), dielectric, and dielectric grating (SiO2). The comparison was conducted to evaluate the sensor's figure of merit (FOM) and limit of detection (LOD) at 830 nm wavelength while optimizing the thickness of metal layer for different concentration of cortisol and keeping other parameters constant. The largest FOM of 20.83 RIU−1 was observed for the composition of IZBSC (40 InF3-20 ZnF2-15 BaF2-20 SrF2-5 CaF2) from InF3-based group, resulting in an exceptional LOD of 0.986 fg/mL with the intensity interrogation method. This represents a tremendous advancement compared to prior reported results. Furthermore, by implementing a topological insulator Bi1.5 Sb0.5 Te1.8 Se1.2 (BSTS) into this sensor with a ZBLAN fiber for the first time, the LOD was reduced to 0.54 fg/mL, demonstrating remarkable progress in cortisol sensing capability best to our knowledge.
Published in: IEEE Photonics Journal ( Volume: 16, Issue: 6, December 2024)
Article Sequence Number: 7101708
Date of Publication: 15 October 2024

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