Abstract:
Early patterning in the Drosophila melanogaster embryo occurs through a complicated network of interactions involving transcription factor proteins and the mRNA of their ...Show MoreMetadata
Abstract:
Early patterning in the Drosophila melanogaster embryo occurs through a complicated network of interactions involving transcription factor proteins and the mRNA of their target genes. One such system is the pattern of hunchback mRNA and its regulation by Bicoid and Kru¿ppel proteins. This system is well-studied, but there is disagreement amongst biologists on how exactly hunchback expression is regulated. We attempt here to provide evidence to distinguish between two models in contention, through system identification. Our general approach is to do nonlinear regression on a parametric, nonlinear partial differential equation model which incorporates transcription, diffusion, and degradation. We perform the regression, analyze the results and then interpret the results in the biological context. We also compare our results to previous work on this system.
Published in: Proceedings of the 48h IEEE Conference on Decision and Control (CDC) held jointly with 2009 28th Chinese Control Conference
Date of Conference: 15-18 December 2009
Date Added to IEEE Xplore: 29 January 2010
ISBN Information: