Abstract:
An image sensor designed with standard 0.18μm CMOS technology is used to construct a DNA microarray scanner. The detection limit of 4590 fluorophores/μm2 is compared with...Show MoreMetadata
Abstract:
An image sensor designed with standard 0.18μm CMOS technology is used to construct a DNA microarray scanner. The detection limit of 4590 fluorophores/μm2 is compared with 4.49 fluorophores/μm2 of a commercial photomultiplier-tube-based microarray scanner. The performance gap can be reduced by improving optical coupling, mechanical alignment, laser power supply noise, improved circuit noise and an increase in the conversion gain. The CMOS sensor offers multiple-pixels for reduced scan time and an integrated analog-to-digital converter.
Published in: 2007 IEEE Custom Integrated Circuits Conference
Date of Conference: 16-19 September 2007
Date Added to IEEE Xplore: 21 January 2008
ISBN Information:
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