The CREDO stack: Theory to practice in cognitive systems engineering

CREDO is a framework for understanding and designing cognitive systems. It has evolved through a long research program starting from empirical studies of human medical expertise, and including extensive theoretical studies and practical development of AI systems in medicine. The results are now being successfully exploited in a wide range of clinical applications, some on a large scale. The unique feature of the CREDO framework is that it spans theory, technology, engineering and practical use of AI in a challenging domain yet in a unified and principled way. This brief retrospective overview covers some of the main results that underpin CREDO and outlines a range of clinical applications and future directions. Technical details can be found in extensive references to published papers. Capabilities of the CREDO software platform are illustrated by more than 50 diverse examples of medical applications in the OpenClinical.net repository http://www.openclinical.net/index.php?id=69.