Magnetic Nanoparticles for Therapy and Diagnostics

The research and utilization of the magnetic nanoparticles in, e.g., biology and medicine have been preferentially oriented on magnetite
${\rm Fe}_{3}{\rm O}_{4}$
and maghemite
$\gamma-{\rm Fe}_{2}{\rm O}_{3}$
. The complex oxides allow a better control of the magnetic properties in a desirable way. We demonstrate this approach on an example of the
${\rm La}_{1-{\rm x}}{\rm Sr}_{\rm x}{\rm MnO}_{3}$
perovskites from the point of view of their use in self-controlled magnetic fluid hyperthermia and increase of contrast in magnetic resonance imaging. With materials possessing suitable values of transition temperature
$T_{\rm C}$
, coercivity and magnetization, the heating power generated by the nanoparticles was estimated by two independent methods and they were finally employed in vitro and in vivo hyperthermia experiments.