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# IEEE Transactions on Biomedical Engineering

### Early Access Articles

Early Access articles are made available in advance of the final electronic or print versions. Early Access articles are peer reviewed but may not be fully edited. They are fully citable from the moment they appear in IEEE Xplore.

## Filter Results

Displaying Results 1 - 25 of 223
• ### Detection of Vesicoureteral Reflux using Electrical Impedance Tomography

Publication Year: 2018, Page(s): 1
| | PDF (691 KB)

Objective: The purpose of this study is to detect vesicoureteral reflux (VUR) non-invasively using electrical impedance tomography (EIT). VUR is characterized by the backflow of urine from the bladder to the kidneys. Methods: Using porcine models, small quantities of a solution mimicking the electrical properties of urine were infused into each ureter. EIT measurements were taken before, during an... View full abstract»

• ### Localization of Activation Origin on Patient-Specific Endocardial Surface by the Equivalent Double Layer (EDL) Source Model with Sparse Bayesian Learning

Publication Year: 2018, Page(s): 1
| | PDF (10528 KB)

Objective: Ablation treatment of ventricular arrhythmias can be facilitated by pre-procedure planning aided by electrocardiographic inverse solution, which can help to localize the origin of arrhythmia. Our aim was to improve localization accuracy of the inverse solution for activation originating on the left-ventricular endocardial surface, by using a sparse Bayesian learning (SBL). Methods: The ... View full abstract»

• ### Variations of Intracellular Ca$^{2}$Mobilization Initiated by Nanosecond and Microsecond Electrical Pulses in HeLa Cells

Publication Year: 2018, Page(s): 1
| | PDF (1363 KB)

Goal: Herein, the variations in transient Ca$^{2}$mobilizations in HeLa cells exposed to a single, non-thermal pulsed electric field (PEF) are described. Methods: Three PEF waveforms categorized by pulse duration and intensity were used to deduce thekinetics involved in Ca$^{2}$mobilization. A fast microscopic fluorescent imaging system a... View full abstract»

• ### Importance of Exposure Duration and Metrics on Correlation between RF Energy Absorption and Temperature Increase in a Human Model

Publication Year: 2018, Page(s): 1
| | PDF (1126 KB)

Objective: This study investigated the influence of absorption metrics and averaging schemes on correlation between RF/microwave energy and induced temperature elevation for plane wave exposures. Methods: A voxel-based, anatomically realistic model of the human body was considered. Correlation of electromagnetic fields and temperature increases were evaluated at several frequencies. Both Specific ... View full abstract»

• ### Optimal B-spline Mapping of Flow Imaging Data for Imposing Patient-specific Velocity Profiles in Computational Hemodynamics

Publication Year: 2018, Page(s): 1
| | PDF (6282 KB)

Objective: We propose a novel method to map patient-specific blood velocity profiles obtained from imaging data such as 2D flow MRI or 3D colour Doppler ultrasound) to geometric vascular models suitable to perform CFD simulations of haemodynamics. We describe the implementation and utilisation of the method within an open-source computational hemodynamics simulation software (CRIMSON). Methods: Th... View full abstract»

• ### Modified Dominant Mode Rejection Beamformer for Localizing Brain Activities When Data Covariance Matrix is Rank Deficient

Publication Year: 2018, Page(s): 1
| | PDF (1181 KB)

Objective: Minimum variance beamformer (MVB) and its extensions fail in localizing short time brain activities particularly evoked potentials because of rank deficiency or inaccurate estimation of data covariance matrix. In this paper, the conventional dominant mode rejection (DMR) adaptive beamformer is modified to localize brain short time activities. Methods: In modified DMR, it is attempted to... View full abstract»

• ### Achieve Automated Organelle Biopsy on Small Single Cells Using a Cell Surgery Robotic System

Publication Year: 2018, Page(s): 1
| | PDF (1217 KB)

Single cell surgery such as manipulation or removal of subcellular components or/and organelles from single cells is increasingly used for the study of diseases and their causes in precision medicine. This paper presents a robotic surgery system to achieve automated organelle biopsy of single cells with dimensions of less than 20 μm in diameter. The complexity of spatial detection of the organelle... View full abstract»

• ### Estimation of refractive index for biological tissue using micro-optical coherence tomography

Publication Year: 2018, Page(s): 1
| | PDF (615 KB)

The refractive index of biological tissue is required for investigating the tissue's optical properties. Efforts have been made to characterize refractive indices of biological tissues at a single wavelength, but it is more convenient to know the Cauchy's coefficients, which provide refractive index over a wide range of wavelengths. We demonstrate a method to noninvasively provide the Cauchy's dis... View full abstract»

• ### Correlation Between Optical Fluorescence and Microwave Transmission During Single-cell Electroporation

Publication Year: 2018, Page(s): 1
| | PDF (516 KB)

Objective: Multimodal characterization of a mammalian cell by optical and microwave techniques simultaneously during electroporation. Methods: Using a coplanar waveguide with a Jurkat cell trapped in the middle of its center conductor, continuous waves at 100 kHz of different amplitudes were applied for 20 s while microwave transmission coefficients at 9 GHz were measured every 0.4 s. Results: The... View full abstract»

• ### Achieving Super-Resolution with Redundant Sensing

Publication Year: 2018, Page(s): 1
| | PDF (887 KB)

Objective: A new technique is presented to enhance the precision of the analog-to-digital (AD) and digital-to-analog (DA) conversion which are fundamental operations of many biomedical information processing systems. In practice, the precision of these operations is always bounded, first by the random mismatch error (ME) occurred during system implementation, and subsequently by the intrinsic quan... View full abstract»

• ### A New Image Similarity Metric for Improving Deformation Consistency in Graph Based Groupwise Image Registration

Publication Year: 2018, Page(s): 1
| | PDF (4995 KB)

Graph-based groupwise image registration (G-GIR) aims to register a group of input images accurately without bias. In G-GIR, an image similarity metric (ISM) is used to construct a graph that links similar images with graph edges. From the built graph, a group center image and the shortest paths linking it to all other images can be determined. The deformation field aligning each image to the grou... View full abstract»

• ### Self-scanned HIFU ablation of moving tissue using real-time hybrid US-MR imaging

Publication Year: 2018, Page(s): 1
| | PDF (25483 KB)

Objective: High Intensity Focused Ultrasound (HIFU) treatment in the abdominal cavity is challenging due to the respiratory motion. In the self-scanning HIFU ablation method the focal spot is kept static and the heating pattern is obtained through natural tissue motion. This paper describes a novel approach for modulating the HIFU power during self-scanning in order to compensate for the effect of... View full abstract»

• ### Individualization of Ultrafiltration in Hemodialysis

Publication Year: 2018, Page(s): 1
| | PDF (1099 KB)

Objective: There are approximately 660,000 end-stage renal disease (ESRD) patients in the USA, with hemodialysis (HD) the primary form of treatment. High ultrafiltration rates (UFRs) are associated with intradialytic hypotension, a complication associated with adverse clinical outcomes including mortality. Individualized UFR profiles could reduce the incidence of intradialytic hypotension. Methods... View full abstract»

• ### Image-Aligned Dynamic Liver Reconstruction Using Intra-Operative Field of Views for Minimal Invasive Surgery

Publication Year: 2018, Page(s): 1
| | PDF (3533 KB)

During hepatic minimal invasive surgery (MIS), 3D reconstruction of a liver surface by interpreting the geometry of its soft-tissues is achieving attractions. One of the major issues to be addressed in MIS is liver deformation. Moreover, it severely inhibits free sight and dexterity of tissue manipulation which causes its intra-operative morphology and soft tissue motion altered as compared to its... View full abstract»

• ### Improvement in Recovery of Hemodynamic Responses by Extended Kalman Filter with Non-Linear State-Space Model and Short Separation Measurement

Publication Year: 2018, Page(s): 1
| | PDF (1459 KB)

Objective: The purpose of this study is to describe the noise reduction in the hemodynamic responses, obtained by functional near-infrared spectroscopy (fNIRS), using the proposed extended Kalman filter (EKF) with a non-linear state-space model, aided by the short separation (SS) measurement. Methods: The authors used the simulated data by adding the synthetic hemodynamic response function (HRF) t... View full abstract»

• ### Alternating Diffusion Map Based Fusion of Multimodal Brain Connectivity Networks for IQ Prediction

Publication Year: 2018, Page(s): 1
| | PDF (4295 KB)

Objective: To explain individual differences in development, behavior, and cognition, most previous studies focused on projecting resting-state functional MRI (fMRI) based functional connectivity (FC) data into a low-dimensional space via linear dimensionality reduction techniques, followed by executing analysis operations. However, linear dimensionality analysis techniques may fail to capture non... View full abstract»

• ### Deep Leaning Based Multi-Modal Fusion for Fast MR Reconstruction

Publication Year: 2018, Page(s): 1
| | PDF (1930 KB)

T1-weighted image (T1WI) and T2-weighted image (T2WI) are the two routinely acquired magnetic resonance (MR) modalities that can provide complementary information for clinical and research usages. However, the relatively long acquisition time makes the acquired image vulnerable to motion artifacts. To speed up the imaging process, various algorithms have been proposed to reconstruct high-quality i... View full abstract»

• ### Augmented Reality to Improve Surgical Simulation. Lessons Learned Towards the Design of a Hybrid Laparoscopic Simulator for Cholecystectomy

Publication Year: 2018, Page(s): 1
| | PDF (1197 KB)

Hybrid surgical simulators based on Augmented Reality (AR) solutions benefit from the advantages of both the box trainers and the Virtual Reality simulators. This paper reports on the results of a long development stage of a hybrid simulator for laparoscopic cholecystectomy that integrates real and the virtual components. We first outline the specifications of the AR simulator and then we explain ... View full abstract»

• ### Compression of Steganographed PPG Signal with Guaranteed Reconstruction Quality Based on Optimum Truncation of Singular Values and ASCII Character Encoding

Publication Year: 2018, Page(s): 1
| | PDF (1145 KB)

Objective: Extraction and analysis of various clinically significant features of photoplethysmogram (PPG) signals for monitoring several physiological parameters as well as for biometric authentication have become important areas of research in recent years. However, PPG signal compression; particularly quality-guaranteed compression, and steganography of patient's secret information is still lagg... View full abstract»

• ### Endovascular Electrical Stimulation - A Novel Hemorrhage Control Technique

Publication Year: 2018, Page(s): 1
| | PDF (1104 KB) |  Media

Objective: In this study we present a novel approach for inducing vasoconstriction by pulsed electrical treatment delivered via endovascular electrodes, which can be used in cases where external access to the vessel is limited. Methods: Using computer simulations, we optimized various geometries of endovascular electrodes to maximize the induced electric field on the arterial wall. Using the optim... View full abstract»

• ### Millimeter-wave Adaptive Glucose Concentration Estimation with Complex-Valued Neural Networks

Publication Year: 2018, Page(s): 1
| | PDF (751 KB)

In this paper, we propose an adaptive glucose concentration estimation system. The system estimates glucose concentration values non-invasively by making full use of transmission magnitude and phase data. Debye relaxation model indicates that, in millimeter wave frequency range, we can acquire both a high sensitivity and a sufficient penetration depth. Based on the physical model, we choose 60-80 ... View full abstract»

• ### Predicting Invasive Disease-Free Survival for Early-stage Breast Cancer Patients Using Follow-up Clinical Data

Publication Year: 2018, Page(s): 1
| | PDF (1360 KB)

Objective: Chinese women are seriously threatened by breast cancer with high morbidity and mortality. The lack of robust prognosis models results in difficulty for doctors to prepare an appropriate treatment plan that may prolong patient survival time. An alternative prognosis model framework to predict Invasive Disease-Free Survival (iDFS) for early-stage breast cancer patients, called MP4Ei, is ... View full abstract»

• ### Automatic Assessment of Full Left Ventricular Coverage in Cardiac Cine Magnetic Resonance Imaging with Fisher Discriminative 3D CNN

Publication Year: 2018, Page(s): 1
| | PDF (9546 KB)

Cardiac magnetic resonance (CMR) images play a growing role in the diagnostic imaging of cardiovascular diseases. Full coverage of the left ventricle (LV), from base to apex, is a basic criterion for CMR image quality and necessary for accurate measurement of cardiac volume and functional assessment. Incomplete coverage of the LV is identified through visual inspection, which is time-consuming and... View full abstract»

• ### Sparse EEG Source Localization Using LAPPS: Least Absolute l-P (0 < p < 1) Penalized Solution

Publication Year: 2018, Page(s): 1
| | PDF (1543 KB)

Objective: The electroencephalographic (EEG) inverse problem is ill-posed owing to the electromagnetism Helmholtz theorem and since there are fewer observations than the unknown variables. Apart from the strong background activities (ongoing EEG), evoked EEG is also inevitably contaminated by strong outliers caused by head movements or ocular movements during recordings. Methods: Considering the s... View full abstract»

• ### Closed Loop Spatial and Temporal Control of Cavitation Activity with Passive Acoustic Mapping

Publication Year: 2018, Page(s): 1
| | PDF (1357 KB) |  Media

Ultrasonically actuated microbubble oscillations hold great promise for minimally invasive therapeutic interventions. While several preclinical studies have demonstrated the potential of this technology, real-time methods to control the amplitude and type of microbubble oscillations (stable vs inertial acoustic cavitation) and ensure that cavitation occurs within the targeted region are needed for... View full abstract»

## Aims & Scope

IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions.

Full Aims & Scope

## Meet Our Editors

Editor-in-Chief
Bin He
Carnegie Mellon University