Data Management of Protein Interaction Networks

Interactomics: a complete survey from data generation toknowledge extraction

With the increasing use of high-throughput experimental assays,more and more protein interaction databases are becoming available.As a result, computational analysis of protein-to-proteininteraction (PPI) data and networks, now known as interactomics,has become an essential tool to determine functionally associatedproteins. From wet lab technologies to data management to knowledgeextraction, this timely book guides readers through the new scienceof interactomics, giving them the tools needed to:

• Generate and store PPI data

• Analyze PPI data and networks

• Develop useful applications

The authors have organized the book according to the workflow ofinteractomics, beginning with data generation and ending withknowledge extraction. Readers will discover how to make full use ofall the databases, tools, and techniques currently available forexploiting interactomics data. They'll learn a broad range ofapproaches for the management and analysis of protein interactiondata, including topological-, database-, data mining-, andontology-based methods. The fundamental principles underlying eachof these methods are presented in detail, alongside theiradvantages and disadvantages.

Throughout the book, case studies enable readers to discover howinteractomics enables researchers to generate, represent, store,analyze, and manage PPI data and networks. Moreover, the authorsdiscuss new and emerging applications developed from interactomicsresearch.

Data Management of Protein Interaction Networks isrecommended for all bioinformaticians and protein researchers whowant to take full advantage of interactomics software tools andmethods in order to enhance their knowledge of biologicalprocesses.