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A 0.18 \mu {\rm m} Biosensor Front-End Based on 1/f Noise, Distortion Cancelation and Chopper Stabilization Techniques

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6 Author(s)
Balasubramanian, V. ; Swiss Center for Electron. & Microtechnol., Neuchatel, Switzerland ; Ruedi, P.-F. ; Temiz, Y. ; Ferretti, A.
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This paper presents a novel sensor front-end circuit that addresses the issues of 1/f noise and distortion in a unique way by using canceling techniques. The proposed front-end is a fully differential transimpedance amplifier (TIA) targeted for current mode electrochemical biosensing applications. In this paper, we discuss the architecture of this canceling based front-end and the optimization methods followed for achieving low noise, low distortion performance at minimum current consumption are presented. To validate the employed canceling based front-end, it has been realized in a 0.18 μm CMOS process and the characterization results are presented. The front-end has also been tested as part of a complete wireless sensing system and the cyclic voltammetry (CV) test results from electrochemical sensors are provided. Overall current consumption in the front-end is 50 μA while operating on a 1.8 V supply.

Published in:

Biomedical Circuits and Systems, IEEE Transactions on  (Volume:7 ,  Issue: 5 )

Date of Publication:

Oct. 2013

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