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360° Fourier Transform Profilometry in Surface Reconstruction for Fluorescence Molecular Tomography

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5 Author(s)
Bi’er Shi ; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China ; Bin Zhang ; Fei Liu ; Jianwen Luo
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Fluorescence molecular tomography (FMT) is an emerging tool in the observation of diseases. A fast and accurate surface reconstruction of the experimental object is needed as a boundary constraint for FMT reconstruction. In this paper, an automatic, noncontact, and 3-D surface reconstruction method named 360° Fourier transform profilometry (FTP) is proposed to reconstruct 3-D surface profiles for FMT system. This method can reconstruct 360° integrated surface profiles utilizing the single-frame FTP at different angles. Results show that the relative mean error of the surface reconstruction of this method is less than 1.4% in phantom experiments, and is no more than 2.9% in mouse experiments in vivo. Compared with the Radon transform method, the proposed method reduces the computation time by more than 90% with a minimal error increase. At last, a combined 360° FTP/FMT experiment is conducted on a nude mouse. Not only can the 360° FTP system operate with the FMT system simultaneously, but it can also help to monitor the status of animals. Moreover, the 360° FTP system is independent of FMT system and can be performed to reconstruct the surface by itself.

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IEEE Journal of Biomedical and Health Informatics  (Volume:17 ,  Issue: 3 )