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High-Frequency Nonlinear Doppler Contrast-Enhanced Ultrasound Imaging of Blood Flow | IEEE Journals & Magazine | IEEE Xplore

High-Frequency Nonlinear Doppler Contrast-Enhanced Ultrasound Imaging of Blood Flow


Separation of perfusion and flow in pre and post injury in rat spinal cord resting on top of vertebral bones. (a) and (b) show the the lower velocity flow following SVD s...

Abstract:

Current methods for in vivo microvascular imaging (<; 1 mm) are limited by the tradeoffs between the depth of penetration, resolution, and acquisition time. Ultrasound Do...Show More

Abstract:

Current methods for in vivo microvascular imaging (<; 1 mm) are limited by the tradeoffs between the depth of penetration, resolution, and acquisition time. Ultrasound Doppler approaches combined at elevated frequencies (<; 7.5 MHz) are able to visualize smaller vasculature and, however, are still limited in the segmentation of lower velocity blood flow from moving tissue. Contrast-enhanced ultrasound (CEUS) has been successful in visualizing changes in microvascular flow at conventional diagnostic ultrasound imaging frequencies (<; 7.5 MHz). However, conventional CEUS approaches at elevated frequencies have met with limited success, due, in part, to the diminishing microbubble response with frequency. We apply a plane-wave acquisition combined with the non-linear Doppler processing of ultrasound contrast agents at 15 MHz to improve the resolution of microvascular blood flow while compensating for reduced microbubble response. This plane-wave Doppler approach of imaging ultrasound contrast agents also enables simultaneous detection and separation of blood flow in the microcirculation and higher velocity flow in the larger vasculature. We apply singular value decomposition filtering on the nonlinear Doppler signal to orthogonally separate the more stationary lower velocity flow in the microcirculation and higher velocity flow in the larger vasculature. This orthogonal separation was also utilized to improve time-intensity curve analysis of the microcirculation, by removing higher velocity flow corrupting bolus kinetics. We demonstrate the utility of this imaging approach in a rat spinal cord injury model, requiring submillimeter resolution.
Separation of perfusion and flow in pre and post injury in rat spinal cord resting on top of vertebral bones. (a) and (b) show the the lower velocity flow following SVD s...
Page(s): 1776 - 1784
Date of Publication: 08 April 2020

ISSN Information:

PubMed ID: 32275589

Funding Agency:


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