Ultrasound induced degradation of hollow PLGA microcapsules

We have investigated the effect of ultrasound energy on the degradation pattern of hollow PLGA microcapsules. These microcapsules work as ultrasound contrast agents, giving an in vitro acoustic enhancement of up to 25 dB. The dose response at 5 and 10 MHz was compared to the degradation pattern of the polymer capsules at the same two frequencies. Controlling the degradation is especially important with regard to drug-loaded microcapsules.