A Wearable Autonomous Colorimetric Sweat Induction System for Sweat Analysis

The wearable biochemical sweat sensor’s capability to provide insight into molecular information of health dynamics ignites sweat analysis as a promising noninvasive diagnosis scheme for precision medicine. Here, we demonstrate, for the first time, a colorimetric sweat induction microfluidic patch, which facilitates on-demand sweat glands activation by agonist coupled electrode and capillary action-based fluidics to collect microliter volumes (~5 μL) of sweat for monitoring its analytes by digital image analysis. The system’s clinical utility demonstrated on a healthy volunteer for sweat pH monitoring flags the way towards other important sweat markers analysis for personalized healthcare.Clinical Relevance— Sweat analysis based on wearable technologies and its correlation with blood analytes pave the way towards non-invasive point-of-care monitoring, as an alternative to blood analysis.