Experimental validation of a hypothesis for lung tumour dynamic characterisation

This paper describes seminal work for using tools from fractional calculus on modelling geometry and dynamical nonlinear effects in a mimicked lung tumour setup. A device and methodology are tailored to verify the hypothesis that presence of tumour in lung will affect the frequency dependent respiratory impedance. The data is analysed in terms of detection and quantification of nonlinear distortion in two situations mimicked by the proposed setup: a normal lung and a tumorous lung. Results indicate the feasibility of this research direction and the paper outlines the opportunities at hand.