Influence of naturally occurring tissue movements on Magnetomotive Ultrasound detection of iron oxide nanoparticles for magnetic drug targeting

Magnetic Drug Targeting (MDT) is a cancer treatment technique that enables a local chemotherapy. For this purpose, chemotherapeutic drugs are bound to magnetic nanoparticles and are accumulated in the tumor area by means of an external magnetic field. In order to adapt the position of the magnet the visualization of nanoparticles is of vital importance for MDT. Magnetomotive Ultrasound (MMUS) enables the sonographic detection of magnetic nanoparticles which are not visible directly using ultrasound imaging techniques due to their weak backscattering. In this connection, image artefacts in MMUS applications can be reduced by means of coded magnetic fields.