Return-to-the-origin probability imaging as indicator of local necrosis

The object of this work is to develop a noninvasive method for detecting local tissue necrosis in RIF-1 murine tumors. The method is based on structural differences between necrotic and viable tissue. By probing the displacement of water molecules in a time, t, it is possible to gather information on the tissue structure. This can be exploited to detect local tissue necrosis in tumors. The return-to-the-origin probability derived from porous media theory is employed to detect local necrosis in tumor.