Study on Reversibility of Genetic Toxicity of TDI in Mice

This article studied whether genetic toxicity of toluene diisocyanate was reversible. Kunming mice were exposed to TDI by respiratory tract for 14 days in 1/8LC
₅₀
, 1/4LC
₅₀
and 1/2 LC
₅₀
dosage and then were feed normally for 14 days. The chromosomal aberrations and the content of RNA & DNA were detected by optical microscope and laser scanning confocal microscope. In 1/4LC
₅₀
and 1/2 LC
₅₀
group, chromosome aberration rate and the RNA / DNA ratio of TDI were higher than control group significantly (P<;0.01). In addition there was no significant difference between 1/4LC
₅₀
and 1/2 LC
₅₀
(p> 0.05). The results showed that the damage of TDI on chromosomes and DNA was repairable, but can not be repaired completely.