Discrete-event based simulation conceptual modeling of systems biology

The protein production from DNA to protein via RNA is a very complicated process, which could be called central dogma. In this paper, we used event based simulation to model, simulate, analyze and specify the three main processes that are involved in the process of protein production: replication, transcription, and translation. The whole control flow of event-based simulation is composed of three parts (events): replication, transcription, and translation. In each part, control flow and events are depending on their final stage event. While in progress, we describe the relationship from DNA to protein in the systematic point of view and we describe each event with more details, where we will show that each event consist of number of sub-events i.e. in order for the DNA to be transcribed into mRNA, the RNA has to go trough five sub-events before a mRNA produced. Although the aim of this paper is to develop an event-based simulation model for protein production rather than the molecular events and chemical reactions that occur during this process, some basic information of molecular events and precursors/molecules that are required for each step of the protein production process are described. By modeling the whole process of central dogma, it is expected to develop the system and to simulate them in much easier ways.