Immobilized macromolecule detection through quadrature microdiffraction

Summary form only given. We demonstrate the fabrication of microstructures on silicon that act as individual microscopic interferometers all operating in quadrature. These microstructures can have dimensions less than a micron, making it possible to fabricate over a billion interferometer elements on single disk the size of a compact disk.. To test the feasibility of detecting biohazards and antigens using this approach, we fabricated a 3-inch silicon wafer with 1024 microstrips of gold, each 20 microns wide and 3 cm long, arranged radially like spokes on a wheel.