Modelling the FRC network of lymph node

This work presents an idealized geometric model of the lymph node (LN) consisting of a set of 'elementary' macroscopic structures such as subcapsular sinus, trabecular sinuses with a special focus on fibroblastic reticular cells (FRC) network. An experimental data driven computational algorithm has been developed to reconstruct the macroscopic structure of FRC network based on high-resolution confocal microscopy data of a murine LN. The FRC geometric model can be further discretized for use in computational studies of lymph and cytokines transport through the LN.