Manual and automatic size measurement of lateral ventricle and central sulci̇ and their compliance with atrophy grade

Diagnosis and treatment of various brain diseases occurring due to aging such as dementia, take an important role in contemporary research for elderly population in the world and in our country with increasing progressively. Cerebral atrophy is a feature observed in dementia patients and described as neuronal loss or cell death affecting part or all of the brain, to determine the presence and severity of atrophy, experts visually evaluate magnetic resonance images of the brain, especially at locations such as lateral ventricles and central sulci. The aim of this study is measuring the sizes (e.g. length, area and volume) of lateral ventricles and central sulci in 3D and to compare these measurements with experts' atrophy ratings. Lateral ventricle width shows high agreement (around 0.84) with atrophy grades.