Biological Networks-Based Analysis of Gene Expression Signatures

Biological networks, such as protein interaction networks and gene coexpression networks, are becoming popular in many studies, including the study of gene signatures of complex diseases. Computational biologists have developed many methods to identify gene signatures by combining gene expression profiles, biological networks, and other related data. Using data on biological networks, researchers also want to integrate different gene signatures by considering the interactions among genes. This chapter provides a brief introduction of gene signatures. Biological network-based identification of gene signatures is described here. Finally, the authors discuss protein interaction network-based integration of different gene signatures.