Interplay of matrices in cartilage synovial fluid combine under moderate and high loadings

The interplay of the constituents of articular cartilage synovial fluid is examined from the biochemical and rheological study on bovine joint. Results show an inverse relationship between the changes in the hyaluronic acid and proteoglycan contents of synovial fluid and articular cartilage with corresponding alterations in the rheological properties of synovial fluid. The study indicates that inter-movement of fluid solutes across the cartilage and synovial fluid plays an important role in the pathophysiology of osteoarthritis.