Development of diagnostic imaging system for regional lymph node micrometastasis with high-frequency ultrasound

It is important of diagnosing not only primary tumors but also metastases accurately. Recently, we have established murine lymph node metastasis model and developed a new method to reconstruct the two- and three-dimensional (2D/3D) vessel structures in the model by using nanobubbles (NBs) and high-frequency ultrasound imaging system. In the present study, we investigated the characteristics of 2D/3D vessel structures in the metastasis model, and compared to normal lymph node. This technique may be useful for early diagnosis of lymph node micrometastasis.