Fine-Grained Diabetic Wound Depth and Granulation Tissue Amount Assessment Using Bilinear Convolutional Neural Network

Diabetes mellitus is a serious chronic disease that affects millions of people worldwide. In patients with diabetes, ulcers occur frequently and heal slowly. Grading and staging of diabetic ulcers is the first step of effective treatment and wound depth and granulation tissue amount are two important indicators of wound healing progress. However, wound depths and granulation tissue amount of different severities can visually appear quite similar, making accurate machine learning classification challenging. In this paper, we innovatively adopted the fine-grained classification idea for diabetic wound grading by using a Bilinear CNN (Bi-CNN) architecture to deal with highly similar images of five grades. Wound area extraction, sharpening, resizing and augmentation were used to pre-process images before being input to the Bi-CNN. Innovative modifications of the generic Bi-CNN network architecture are explored to improve its performance. Our research generated a valuable wound dataset. In collaboration with wound experts from University of Massachusetts Medical School, we collected a diabetic wound dataset of 1639 images and annotated them with wound depth and granulation tissue grades as labels for classification. Deep learning experiments were conducted using holdout validation on this diabetic wound dataset. Comparisons with widely used CNN classification architectures demonstrated that our Bi-CNN fine-grained classification approach outperformed prior work for the task of grading diabetic wounds.


I. INTRODUCTION
Diabetes mellitus is a serious chronic disease that affects an estimated 425 million people worldwide (or 8.8% of the adult population) [1].In the U.S. in 2015, about 23.1 million people of all ages (7.2% of the U.S. population) had diagnosed diabetes [2].In diabetic populations, diabetic wounds occur easily due to reasons including higher frequency and intensity of mechanical changes in conformation of the bony architecture, peripheral neuropathy, and atherosclerotic peripheral arterial disease [3], [4].Diabetic wounds have a lifetime prevalence estimated between 12% and 25% [2] and has a high recurrence rate between 7.8% [5] to 48.0% [6].
The associate editor coordinating the review of this manuscript and approving it for publication was Haiquan Zhao.
Diabetic wounds may take months to years to heal and require regular checkups by wound nurses who debride the wound, inspect its healing progress and recommend visits to wound experts when necessary.Consistent and accurate wound care is crucial for proper diabetic wound healing and delays in visiting a wound specialist could increase the risk of lower extremity amputation or even death [2].However, a shortage of wound experts especially in rural areas can cause late diagnosis and poor wound care [7].Moreover, unnecessary hospital visits increase the workload of clinicians and add an avoidable financial burden for patients.A smartphone photo-based wound assessment system that patients or visiting nurses can use in the patients' homes is a promising solution to these problems.Since 2011, our group has been researching and developing the Smartphone Wound Analysis and Decision-Support (SmartWAnDS) system, which will autonomously analyze wound images captured by patients' smartphone cameras and generate wound care decisions.SmartWAnDS will support decisions made by wound nurses in remote locations, thus standardizing the care of diabetic wounds.The Smart-WAnDS system would also enable patients get feedback anytime between visits, engaging them in their care.Grading and staging of diabetic ulcers is the first step of effective treatment, which has been shown to significantly affect and predict the wound's outcome.Increases in ulcer grades have been found to correlate to increases in amputation rates [8], [9].Consequently, our research group is focusing on an autonomous photo-based wound severity grading system.
Wound depth and granulation tissue amount are two important attributes that indicate the wound's severity during grading.However, machine learning classification is challenging because wound depths and granulation tissue amount of different severities can appear quite similar (See Figures 1 and 2).Fine-grained image classification is an emerging intra-class image classification approach, which tries to recognize sub-categories in the same main category.These sub-categories usually look quite similar (e.g.recognizing different sub-types of flowers [23], [24], plants [25], [26], insects [27], [28], birds [29]- [38], dogs [39]- [42], vehicles [37], [43] and shoes [44]) and do not have obvious discriminative features such as different shape, color and texture, making classification challenging.In this paper, we utilize the fine grained neural networks approach to improve the accuracy of classifying wound depth and granulation tissue amounts attributes compared to prior work.
Our rubric for wound grading is the Photographic Wound Assessment Tool (PWAT)) [10]- [12], which has been proposed by wound assessment experts to enable novices accurately grade wounds and has been generally accepted as a standard for photo-based wound evaluation.PWAT uses eight criteria for grading wound healing: size, depth, necrotic tissue type, total amount of necrotic tissue, granulation tissue type, total amount of granulation tissue, edges and periulcer skin viability.Each PWAT criterion can be scored from 0 to 4 (good to bad), yielding a maximum total score of 32.Details of the PWAT assessment criteria for depth and total amount of granulation tissue are shown in Table 1.Since PWAT scores for each attribute ranges from 0 to 4, we consider the grading of the wound depth and granulation tissue amount of diabetic wounds as a five-class image classification task.
Previous photo-based automatic wound assessment research mostly used traditional machine learning approaches with hand-crafted image descriptors such as color and textural features [13], color histograms [14], local binary patterns (LBP) [15], morphological and topological characteristics [16].There has been little research into image-based wound depth evaluation.Acha et al extracted first-order statistical features [17] and colour and texture features [18] for wound diagnosis.In summary, these approaches all utilize handcrafted image descriptors with unsupervised approaches for classification, which may not effectively distinguish similar wound attribute sub-classes.
Following the success of deep neural network in many computer vision and image analysis tasks, they are increasingly being used for wound image analyses.Convolutional Neural Networks (CNNs) are the most widely used architectures for wound image analyses.In order to classify healthy skin and the wounds, CNN-based DFUNet [19] and LeNet [20] were proposed.CNN architectures performed well for wound tissue type classification [21], [22].However, these prior deep learning methods adopted CNN architectures for classifying wound images into two or three very distinct classes (e.g.Skin vs wound vs background).In contrast to prior work, our goal was to classify wound depth and granulation tissue amount into five grades ranging from 0 to 4 based on the PWAT grading rubric.As wound depth and granulation tissue amount of different grades do not have obvious distinguishing visual characteristics, our classification task was challenging.
To solve these problems, we innovatively adopted a Bi-linear CNN (Bi-CNN) architecture specifically designed for fine-grained classification for grading diabetic wounds into five classes.The main contributions of this paper are four-fold: 1) In collaboration with wound experts, we created a large diabetic wound image dataset that we then annotated with their corresponding wound depth and granulation tissue amount based on the PWAT rubric.2) We innovatively applied a Bi-CNN fine-grained classification deep neural network to deal with the challenging task of recognizing different grades of wound depth and granulation tissue amount, which are highly similar.3) We modified the generic Bi-CNN network architecture and adopted several pre-processing techniques to improve the Bi-CNN's performance in automatic diabetic wound grading.4) Our results show that our modified Bi-CNN outperformed other widely used CNN classification architectures, demonstrating that the fine-grained classification approach can significantly improve wound attribute classification accuracy.
To the best of our knowledge, this is the first work to classify wound depth and granulation tissue on a 5-point scale, and the first attempt to adopt state-of-the-art finegrained classification deep neural networks for wound image analyses.Our experimental results showed that our proposed approach is promising for diabetic wound analyses.
The rest of this paper is organized as follows: Section 2 summarizes related work, highlighting their differences with our work.Our methodology is described in Section 3. Sections 4 presents the wound image data set utilized in our study and the implementation details of model training.Our analyses, results and findings are presented in Section 5.In Section 6 we discussed possible improvements and suggest directions for future work.Finally, in Section 7 we conclude our work.

II. RELATED WORK
Traditional computer vision classification approaches based on manual feature extraction are not effective solutions for sub-classes that appear quite similar.Thus, we utilize finegrained deep classification neural networks to learn latent discriminative features from our diabetic wound dataset.Nejati et al [48] is the only work we found using fine-grained deep neural networks for wound tissue classification.However, they utilized AlexNet, an image recognition architecture that is not specifically designed for fine-grained classification as their neural network for tissue classification.Also, they addressed the wound tissue classification problem, for which manually extracting features such as color, shape and texture can be an effective approach.In contrast, our depth and granulation tissue amount grading task is more challenging as the class differences cannot be captured by obvious visual features.
To the best of our knowledge, our work is the first that uses a deep neural network specifically designed for finegrained classification for the analyses of fine classes of wound attribute grading.

A. BILINEAR CONVOLUTIONAL NEURAL NETWORK FOR WOUND GRADING (Bi-CNN)
The Bilinear Convolutional Neural Network (Bi-CNN) architecture was first proposed by Lin et al [37].In their paper, the Bi-CNN performed well on a birds dataset with images in 200 categories, an aircraft dataset with 100 categories and cars dataset with 196 categories.The Bi-CNN consists of two parallel stream feature extractors based on CNNs whose outputs are multiplied using the outer product at each location of the image and pooled across locations to obtain a bi-linear vector as the learned image descriptor, which is followed by the fully connected layer.
In our work, we utilized the VGG16 architecture [49], which was pre-trained on more than 14 million images from ImageNet [50] as the basic network for both streams of our Bi-CNN architecture for wound grade classification.We also compared the Bi-CNN approach to the classic VGG16 network, which has 16 weight layers, 13 convolutional and 3 fully connected layers.Based on this architecture, we utilized five convolutional blocks for both streams and then the feature outputs were combined at each location using the matrix outer product with sum pooling.
The bilinear feature BF is calculated by: where L is the location of current pixel, I A and I B are input images, for our proposed method they are same.S A and S B are the two feature outputs extracted from Stream A and Stream B respectively.And then we adopted sum pooling to obtain the bilinear vector φ(I ) by calculating: The bilinear vector p = φ(I ) obtained is then passed through a signed square root step (q ← − sign(p) √ |p|), followed by l2 normalizations (r ← − q/ q 2 ) that have been shown to improve the model's performance in practice [37].
After generating the bilinear vector, a dropout layer is applied to avoid overfitting, followed by a soft-max layer.Fig. 3 is a detailed list of parameters of our proposed Bi-CNN architecture for wound grade classification.The outer product captures pairwise correlations between feature channels and can model part-feature interactions.For example, for the classification of wound depth grades, one of the networks is a part detector that locates edges of the wound and the other network is a local feature extractor that recognizes the depth of the wound.Thus, as this architecture can model local pairwise feature interactions [37], it is particularly useful for finegrained categorization.The pipeline of our proposed Bi-CNN architecture for the grading of wound depth and granulation tissue amounts is shown in Fig. 4.

B. END-TO-END TRAINING
Our network for wound severity grading can be trained using an end-to-end approach.All the parameters in the network were trained by back-propagating the gradients of the classification loss.We adopted the cross-entropy loss function in our experiments.Based on the chain rule, back propagation of gradients through bilinear pooling is shown in Fig. 5. dE/dS A and dE/dS B are the gradients of the loss function with regard to the feature outputs S A (from stream A) and S B (from stream B) respectively.Thus, we have:   For other layers, the gradients before bi-linear pooling and in the classification layer are straightforward and can be computed using the chain rule.

III. MATERIALS AND IMPLEMENTATION DETAILS
Our proposed wound evaluation system consists of three major steps: image pre-processing, fine-grained neural network model training and then using the trained model for wound grading.Fig. 6 shows the flow diagram of our proposed wound evaluation system.In the following, we will describe the wound image dataset we utilized, after which we cover in detail each of the stages of our approach.

A. WOUND IMAGE DATASET
All the images we used for the study of wound evaluation systems were acquired in one of three ways.First, we acquired 114 wound images captured with a wound imaging box [51], which maintained a consistent, homogeneous lighting environment for imaging the wound.Second, 202 images were gathered from wound images publicly available on the Internet, which were mostly captured from a relatively perpendicular angle.Third, 1323 patient wound images collected at the University of Massachusetts Medical School (UMMS) were received after IRB approval for our use.These images had large variations in lighting, viewing angles, wound types and skin texture.In total, we gathered 1639 wound images of diabetics from these three sources for inclusion in our wound dataset.For all the experiments we conduct five-fold holdout validation, each fold had 1477 images for training and 162 images for testing.The number and percentage of images in each class are shown in Table 2.

B. PRE-PROCESSING
In our proposed method, we adopted four pre-processing steps to facilitate good feature extraction.One step was specific to our wound classification problem, while two others were standard pre-processing steps used to prepare the images before inputting them into deep networks.The details of our pre-processing steps are as follows.

1) IMAGE PATCHES FOR TRAINING
As most of the original wound images had large background regions (an example is shown in Fig. 7 (a)), if such images are directly classified, the deep network will learn most of the visual features of the background and thus will not accurately learn wound features.Thus, in our proposed method, we first segmented the target wound region (segment) out using an annotation app proposed in our previous research [52] from which we generated a wound mask.A view of this annotation app is shown in Fig. 8.
After segmentation, we derived a bounding box of the recognized wound area, and cropped the images using these bounding boxes to create wound image patches.Finally, all the image patches were cropped to dimensions of 256 * 256 * 3 pixels, and were sometimes resized again according to the needs of different deep networks in our experiments.An example of the image patch generation is shown in Fig 7.

2) IMAGE ENHANCEMENT
In order to improve the performance of fine-grained deep neural network, we sharpened input wound images to enhance their features and make the textures of the wound image    clearer.An example of a sharpened wound image is shown in Fig. 9.

3) RESIZING
Since all pre-trained networks used in our proposed method and the approaches we compared against expect input images to be of a specific size during training, we resized all images to a standard dimension of 448 * 448 * 3 and subtracted the mean of the image before propagating it though the network.

C. MODEL TRAINING
We adopted a two-step model training strategy with transfer learning and fine-tuning steps, which are expounded on below.

1) TRANSFER LEARNING ON WOUND DATA SET
Transfer learning is a commonly used approach in deep learning where a model trained on one task is used as the starting point of a new related task.By learning a model transferred from pre-trained networks, we are able to take advantage of the abundant data utilized and attributes learned by the pretrained network.Thus, we ran our wound images through the pre-trained networks and took the output of the FC layers as was done in some prior work [53], [54].
In our work, we first applied transfer learning by freezing all parameters of the convolution blocks and added a dropout layer and a five-way soft-max layer on top of the network for 5 wound grades and then trained the network.The network is trained by minimizing the cross-entropy loss, as shown in formula (5). and where k is the number of image categories, t pj is the function that indicates the pth image belongs to class j.θ represents the parameters of the softmax classifier.ln(y j (x p , θ) is the network output of the pth image.
For transfer learning, we adopted 1e-8 as weight decay rate, batch size was set as 16 for training with a relatively high base learning rate as 1.The initial weights of the modified layer were generated using the Kaiming uniform approach [55].
After training for about 20-30 epochs, the Bi-CNN classification outputs became stable.We utilized Stochastic Gradient Descent with Momentum (SGDM) as the optimizer in all our experiments.

2) FINE-TUNING THE PROPOSED WOUND GRADING DEEP NEURAL NETWORK
Simply applying transfer learning (i.e. using pre-trained networks without fine tuning) achieved relatively good classification results (shown in Table 6).We then hypothesized that fine-tuning the pre-trained networks using diabetic wound images would yield higher quality features from the images.We fine-tuned the entire model and all layers using backpropagation for about 20-30 epochs at a relatively small learning rate (0.0001), keeping all other input parameters the same with transfer learning.Our accuracy increased around 5% for the wound depth test dataset and 8% for granulation tissue amount test data set, which will be detailed in Section IV-D.

A. EVALUATION METRICS
Our classification approach was evaluated using two performance measures: accuracy and weighted F1 score [56].We also analyzed the classification performance of each class by showing the confusion matrix.
Accuracy is the ratio of the number of images accurately classified by the algorithm out of the total number of images in the test dataset, and is calculated as: We also adopted weighted F1 score as an evaluation index which is defined as: where P i and R i stands for precision and recall of class i, which can be calculated by: where for these two metrics, TP i represents the number of True Positive of class i, FP i is the number of False Positives of class i, TN i for True Negative of class i and FN i for False Negative of class i. w i is the weight and calculated as the proportion of class i images in the test dataset.

B. CHOOSING THE BEST DROPOUT RATE
In order to avoid over fitting in the training process and achieve a more generalized model, we added a dropout layer before the softmax layer.The dropout rate was chosen experimentally leading us to set the optimal dropout rate for wound depth images as 0.2, and for granulation tissue amount as 0.3.The performance of our Bi-CNN with different dropout rates are shown in Table 3 and Table 4.We selected the dropout rate that yielded a high test set accuracy with a relatively small accuracy gap between the train and test accuracies, which indicates that the model is not overfitting.

C. INFLUENCES ON DIFFERENT FULLY CONNECTED LAYER CONSTRUCTIONS
We explored the influences of two different fully connected layer architectures and compared their classification accuracies.First, we adopted an architecture with 3 fully connected layers after bi-linear pooling, shown in Table 5.The experimental results were obtained by setting the base learning rate as 0.01 with 60 epochs.Secondly, we explored an architecture using one Fully-Connected (FC) layer mapped to a softmax layer as was introduced in Section II-A.For comparison, the results are obtained by only re-training the Fully Connected (FC) layers with the convolutional layers frozen.The details are shown in Table 6.
From Table 6, we can see that simply using one FC layer yielded the best results.Hence, in our following experiments, we adopted a single FC layer architecture.

D. ACCURACY AND STABILITY ANALYSES
To better evaluate the performance of our proposed wound grading network, in our experiments, we adopted five-fold holdout validation.We extracted five sets of test images, ensured no overlap between sets and equal proportions of the different grades of original diabetic wound images in each set.Our final results are the average classification accuracy of the five folds.In the confusion matrices, the numbers on diagonal line represent images that were correctly classified.We can see that the majority of test images are on diagonal line or near it.For our wound grading task, numbers above the diagonal line indicate that the wound severity has been over estimated, in which case patients will be recommended to visit a wound expert for an unnecessary examination and further treatment.Although such incorrectly scored images will increase costs to the health care system, they will not affect the patients' health adversely.However, of greater concern are the numbers below the diagonal line in the confusion matrices, which indicate that the wound severity has been underestimated.Such patients may need to visit the wound clinic, but our system will not correctly assess this.

E. ERROR ANALYSIS OF MIS-CLASSIFIED WOUND IMAGES
Next, we performed error analysis by qualitatively assessing the reason individual images were mis-classified.We discovered that unstable lights, blurring, low resolution and controversial labels were the most common causes of misclassification, accounting for about 30% of mis-classified images.Some examples of such images are shown in Following analyses, we believe that additional image preprocessing techniques could be used to deal with uncertain environments while taking photos, mitigating the effects of blurred, bad illumination, low resolution images on wound grading.Additionally, patients could be given picture-taking guidelines to improve the quality of wound images they take for assessment by our system and wound experts.
By comparing our Bi-CNN approach with other CNN architectures that have shown excellent performance on other classification tasks, we see that adopting the fine-grained classification idea for the wound grading problem improved performance and demonstrated the effectiveness of our proposed approach.

V. DISCUSSION AND FUTURE WORK A. MITIGATING CLASS IMBALANCE
As shown in Table 2, we noticed that the number of images in different classes are not well-balanced, as there are 52.6%wound depth images in grade 2, 62.3% wound granulation tissue amount images in grade 4. It is common practice to balance datasets in such cases using data augmentation to avoid unbalanced datasets.By adopting horizontal flip, vertical flip and translation, we augmented the dataset to balance all classes, before applying our proposed architecture.In our experiments, this data augmentation did not improve our experimental results.In fact, our test set accuracy dropped by around 2%.Therefore, we did not explicitly address class imbalance in our approach, nor does prior work by Matsunaga et al. [60]; Barata et al. [61]; Menegola et al. [62], the three top teams of the ISIC 2017 contest.In future work, collecting more diabetic wound images especially for classes with fewer images now will be important to facilitate robust model training.

B. EXPLORING ADDITIONAL PRE-PROCESSING TECHNIQUES
In order to obtain clearer images for training our model, pre-processing techniques for image deblurring, image super resolution and illumination correction will be another important direction.

C. INVESTIGATING THE EFFECTS OF DOWNSAMPLING WOUND IMAGES
The pre-trained VGG16 networks we utilized for both Bi-CNN streams of our proposed wound grading architecture required resizing images to a certain dimension.Resizing may have caused some valuable information to be lost during the down sampling step.So in the subsequent research, we will address this problem to reduce loss of information.

D. FINE-GRAINED CLASSIFICATION OF MORE WOUND ATTRIBUTES
Adopting state-of-the-art fine-grained techniques on diabetic wound grading of other PWAT aspects such as size, necrotic tissue type, edges and periulcer skin viability will be addressed in our future research.

VI. CONCLUSION
In this paper, we proposed a fine-grained diabetic wound grading method based on the Bi-CNN deep neural network.
To the best of our knowledge, this is the first attempt at using a fine-grained deep neural network for wound healing grade classification of five classes.We evaluated the wound healing grades for wound depth and granulation tissue amount guided by ground truth labels provided by wounds experts.We also adopted pre-processing techniques and modified the Bi-CNN architecture to better adapt to the diabetic wound grading task.In comparisons with other commonly used CNN networks, our experimental results show the effectiveness of using fine-grained deep neural network for the diabetic wound grading task.
The results of our proposed approach on diabetic wound grading reveal a promising direction for analyzing wound images that are highly similar and do not have obvious distinguishing visual features for classification.The generalization of the proposed approach for other medical imaging classification tasks is a subject for future work.

FIGURE 3 .
FIGURE 3. Proposed Bi-CNN architecture and parameters for wound grading.

FIGURE 4 .
FIGURE 4. The pipeline of Bi-CNN based diabetic wound grading architecture.

FIGURE 5 .
FIGURE 5. Back propagation of gradients through bilinear pooling.

FIGURE 6 .TABLE 2 .
FIGURE 6. Flow diagram of the proposed wound evaluation system.TABLE 2. Statistics of our collected data set.

FIGURE 7 .
FIGURE 7.An example of an image patch generation.(a) Captured wound image (b) Segmentation mask for wound (c) Wound image patch.

FIGURE 8 .
FIGURE 8.A view of annotation app.(a) Annotated wound image (b) Wound mask.

FIGURE 9 .
FIGURE 9. Image sharpening process.(a) the original wound image patch.(b) the image patch after sharpening.
4) IMAGE AUGMENTATION While our dataset contained images, we needed more images in order to achieve a robust deep learning model.Image augmentation is a commonly used technique to enlarge the training dataset by creating variations of each image in the training dataset to yield more generalized deep neural networks.In our experiments, we created variants of each training image that were rotated by 90, 180 and 270 degrees' as augmentations.Fig. 10 shows an augmentation example.

FIGURE 11 .
FIGURE 11.Training progress of depth and granulation tissue amount data set: the Accuracy and the loss history of best performing model on five-fold holdout validation.(a)-(b) are the results of depth dataset.(c)-(d) are the results of granulation tissue mount dataset.
Fig 11 shows a sample of our training accuracy trajectory and the loss history of the best performing model on five-fold holdout validation based on the depth and granulation tissue amount datasets respectively.

FIGURE 12 .
FIGURE 12. Box plot of changes in accuracy across five folds.

Fig 11
Fig 11 shows that our proposed network for wound grading converges very fast, obtaining a stable accuracy and train loss after around 20 epochs, which also demonstrates good stability of the proposed method.The accuracy of the fivefold holdout validation experiment is shown in Table 7 and analyzed using box plots shown in Fig 12.The best accuracy for wound depth and granulation tissue amount grading are both 84.6%.To evaluate the classification accuracy of each class, we generated confusion matrices for the test set with the best accuracy for wound depth and granulation tissue amount classification, which are shown in Fig 13 and Fig 14.In the confusion matrices, the numbers on diagonal line represent images that were correctly classified.We can see that the majority of test images are on diagonal line or near it.For our wound grading task, numbers above the diagonal line indicate that the wound severity has been over estimated, in which case patients will be recommended to visit a wound expert for an unnecessary examination and further treatment.Although such incorrectly scored images will increase costs to the health care system, they will not affect the patients' health adversely.However, of greater concern are the numbers below the diagonal line in the confusion matrices, which indicate that the wound severity has been underestimated.Such patients may need to visit the wound clinic, but our system will not correctly assess this.
which have shown excellent performance in previous classification tasks.VGGNet was the runner-up in ImageNet Large Scale Visual Recognition Challenge (ILSVRC) in 2014, while AlexNet and ResNet were the winners of the challenge in 2012 and 2015, respectively.Densenet paper won CVPR best paper award in 2017.By adopting the same holdout folds for test, we obtained the experimental results and the best accuracy of different CNN architectures are shown in Table

FIGURE 15 .
FIGURE 15.Examples of common causes of mis-classified wound depth image examples.

FIGURE 16 .
FIGURE 16.Examples of common causes of mis-classified granulation tissue amount image examples.

TABLE 1 .
PWAT assessment rubric for wound depth and granulation tissue amount.

TABLE 3 .
performance with different dropout rates on wound depth images.

TABLE 4 .
The performance with different dropout rates on granulation tissue amount.

TABLE 5 .
Parameters of 3 fully connected layers architecture.

TABLE 6 .
Results obtained by different Fully Connected (FC) layer architectures.WD represents Wound Depth and GTA stands for Granulation Tissue Amount.

TABLE 7 .
Results of the five-fold holdout validation experiment using various evaluation metrics.

FIGURE 13 .
Confusion matrix of wound depth dataset.The accuracy is 84.57%.
FIGURE 14. Confusion matrix of granulation tissue amount dataset.The accuracy is 84.57%.

TABLE 8 .
The results of different CNN architectures.WD represents wound depth and GTA stands for granulation tissue amount.