Vibrational spectroscopic investigation on photocatalytic reaction of titanium dioxide (IV) against a synthetic antibacterial agent using THz and Raman spectroscopy

We investigated about yellowing phenomenon of the light protect film-coated tablet which contains quinolone antibacterial agent using THz and Raman spectroscopy. Anatase-type titanium dioxide (IV) (anaTiO
₂
) is usually used for light-shielding film coating, but it has photocatalytic property. UV exposed Ciprofloxacin hydrochloride monohydrate (CPFX.HCl.H
₂
O), and mixture of anaTiO
₂
and CPFX.HCl.H
₂
O, etc. were measured using THz and Raman spectroscopy. According to spectral analysis, it is indicated that a photocatalytic effect of anaTiO
₂
would promote dehydration and amorphillization of CPFX.HCl.H
₂
O. It suggests that spectroscopic analysis of THz region is applicable to detect degradation of CPFX.HCl.H
₂
O due to photocatalytic reaction of anaTiO
₂
.