A Detection of Tissue Electroporation with Very Short High Voltage Impulse

Electrical properties i.e. conductance of biological tissues have been studied to understand electro-poration (EP). The increase of the electrical conductance after short electric pulses has been considered as an important indication of EP. In this paper an attempt has been made to detect EP during single electric pulse from experimental data. The conductance data collected from EP of a sheep muscle tissue using single exponentially decay pulse is analysed. It has been found that the EP parameter depends on pulse characteristics such as pulse magnitude and pulse width. By analyzing the change of root mean square (rms) conductance obtained from experimentation, it has been found that the conductance properties can be described by a set of voltage and capacitance equations which takes a form of linear model. There is a change of tissue conductance when exposed to a high pulsed electric field. Mean rms conductance increase and the higher the pulse voltage the higher the equivalent conductance. It can be noted that single impulse exponentially decay from capacitor discharge based impulse generator, with maximum voltage and capacitance of 1000 Volt and 8.8 nF produce only a very short time pore openings in order of less than 500 microseconds.