A MEMS-Based Flexible High-Density Brain Electrode for Multi-Modal Neural Encoding/Decoding

We report a conformal flexible brain electrode array with 1024-recording sites within 1×1 cm
²
through multilayer wiring for high-density and high-quality recording of neural activity. Compared with existing cortical electrode applied in clinic, our electrode array has one order of magnitude enhancement in terms of the spatial resolution. In addition, water-soluble silk film is served as the supporting layer to make the ultrathin device easier to manipulate and ensures the conformal wrapping over the curved cortex after its dissolution. Based on the fabricated electrode array, effective neural decoding has been achieved, dynamic processes of normal status, the initial status after induced epilepsy, the status of high frequency seizure, the status of remission after medication, and the succedent recovery status can be efficiently distinguished.