In vivo investigation of DMSA-coated magnetic fluid

Summary form only given. Magnetic fluids (MFs) have been used as a promising technological basis for biomedical applications. In the present study a biocompatible magnetic fluid (BMF) sample is given as an intravenous bolus dose to mice. Magnetic resonance (MR) and light microscopy (LM) are used to investigate the biodistribution of the nanomagnetic-based material over several organs and the time-decay of the BMF sample in the blood circulation, up to four hours after injection. The BMF sample used in this study contains magnetite nanoparticles surface-coated with DMSA to obtain a stable sample at physiological pH and salinity.