A model of vagal control of sinoatrial rhythm

The single pacemaker cell model of Wilders et. al. (1991) has been modified to simulate the complex negative chronotropic response of cardiac period to brief vagal stimulation. Equations have been added to describe the muscarinic K/sup +/ current i/sub K,ACh/ the [ACh]-modulated pacemaker current i/sub f/, and acetylcholine uptake and release by vagal stimulation. The resulting model is able to reproduce the experimentally observed triphasic response of cardiac period following brief vagal stimulation.